3msh
From Proteopedia
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{{STRUCTURE_3msh| PDB=3msh | SCENE= }} | {{STRUCTURE_3msh| PDB=3msh | SCENE= }} | ||
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===Crystal structure of Hepatitis B X-Interacting Protein at high resolution=== | ===Crystal structure of Hepatitis B X-Interacting Protein at high resolution=== | ||
| + | {{ABSTRACT_PUBMED_21059355}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/HBXIP_HUMAN HBXIP_HUMAN]] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.<ref>PMID:12773388</ref> <ref>PMID:22980980</ref> | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:021059355</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Garcia-Saez, I.]] | [[Category: Garcia-Saez, I.]] | ||
[[Category: Skoufias, D.]] | [[Category: Skoufias, D.]] | ||
| + | [[Category: Alpha-beta protein]] | ||
| + | [[Category: Profilin-like fold]] | ||
| + | [[Category: Protein binding]] | ||
| + | [[Category: Roadblock/lc7 domain superfamily]] | ||
Revision as of 20:55, 17 April 2013
Contents |
Crystal structure of Hepatitis B X-Interacting Protein at high resolution
Template:ABSTRACT PUBMED 21059355
Function
[HBXIP_HUMAN] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.[1] [2]
About this Structure
3msh is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Garcia-Saez I, Lacroix FB, Blot D, Gabel F, Skoufias DA. Structural Characterization of HBXIP: The Protein That Interacts with the Anti-Apoptotic Protein Survivin and the Oncogenic Viral Protein HBx. J Mol Biol. 2010 Nov 6. PMID:21059355 doi:10.1016/j.jmb.2010.10.046
- ↑ Marusawa H, Matsuzawa S, Welsh K, Zou H, Armstrong R, Tamm I, Reed JC. HBXIP functions as a cofactor of survivin in apoptosis suppression. EMBO J. 2003 Jun 2;22(11):2729-40. PMID:12773388 doi:10.1093/emboj/cdg263
- ↑ Bar-Peled L, Schweitzer LD, Zoncu R, Sabatini DM. Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Cell. 2012 Sep 14;150(6):1196-208. doi: 10.1016/j.cell.2012.07.032. PMID:22980980 doi:10.1016/j.cell.2012.07.032
