3ml4

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{{STRUCTURE_3ml4| PDB=3ml4 | SCENE= }}
{{STRUCTURE_3ml4| PDB=3ml4 | SCENE= }}
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===Crystal structure of a complex between Dok7 PH-PTB and the MuSK juxtamembrane region===
===Crystal structure of a complex between Dok7 PH-PTB and the MuSK juxtamembrane region===
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{{ABSTRACT_PUBMED_20603078}}
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==Function==
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[[http://www.uniprot.org/uniprot/DOK7_MOUSE DOK7_MOUSE]] Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK.<ref>PMID:16794080</ref> <ref>PMID:20603078</ref>
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{{ABSTRACT_PUBMED_20603078}}
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==About this Structure==
==About this Structure==
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3ML4 is a 8 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ML4 OCA].
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[[3ml4]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ML4 OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:20603078</ref><references group="xtra"/>
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<ref group="xtra">PMID:020603078</ref><references group="xtra"/><references/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Bergamin, E.]]
[[Category: Bergamin, E.]]
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[[Category: Signaling protein]]
[[Category: Signaling protein]]
[[Category: Tyrosine phosphorylation]]
[[Category: Tyrosine phosphorylation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 14 16:21:06 2010''
 

Revision as of 20:56, 17 April 2013

Template:STRUCTURE 3ml4

Contents

Crystal structure of a complex between Dok7 PH-PTB and the MuSK juxtamembrane region

Template:ABSTRACT PUBMED 20603078

Function

[DOK7_MOUSE] Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK.[1] [2]

About this Structure

3ml4 is a 8 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Bergamin E, Hallock PT, Burden SJ, Hubbard SR. The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization. Mol Cell. 2010 Jul 9;39(1):100-9. PMID:20603078 doi:10.1016/j.molcel.2010.06.007
  1. ↑ Okada K, Inoue A, Okada M, Murata Y, Kakuta S, Jigami T, Kubo S, Shiraishi H, Eguchi K, Motomura M, Akiyama T, Iwakura Y, Higuchi O, Yamanashi Y. The muscle protein Dok-7 is essential for neuromuscular synaptogenesis. Science. 2006 Jun 23;312(5781):1802-5. PMID:16794080 doi:312/5781/1802
  2. ↑ Bergamin E, Hallock PT, Burden SJ, Hubbard SR. The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization. Mol Cell. 2010 Jul 9;39(1):100-9. PMID:20603078 doi:10.1016/j.molcel.2010.06.007

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