2y9h

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[[Image:2y9h.png|left|200px]]
 
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{{STRUCTURE_2y9h| PDB=2y9h | SCENE= }}
{{STRUCTURE_2y9h| PDB=2y9h | SCENE= }}
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===STRUCTURE A OF CRISPR ENDORIBONUCLEASE CSE3 BOUND TO 19 NT RNA===
===STRUCTURE A OF CRISPR ENDORIBONUCLEASE CSE3 BOUND TO 19 NT RNA===
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{{ABSTRACT_PUBMED_21572442}}
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==Function==
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[[http://www.uniprot.org/uniprot/Q53WG9_THET8 Q53WG9_THET8]] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Processes pre-crRNA into individual crRNA units, but may not actually undergo enzyme turnover, retaining the crRNA product. Generates a 2',3'-cyclic phosphodiester.<ref>PMID:21572442</ref> <ref>PMID:21572444</ref>
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{{ABSTRACT_PUBMED_21572442}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:021572442</ref><references group="xtra"/>
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<ref group="xtra">PMID:021572442</ref><references group="xtra"/><references/>
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
[[Category: Doudna, J A.]]
[[Category: Doudna, J A.]]

Revision as of 20:57, 17 April 2013

Template:STRUCTURE 2y9h

Contents

STRUCTURE A OF CRISPR ENDORIBONUCLEASE CSE3 BOUND TO 19 NT RNA

Template:ABSTRACT PUBMED 21572442

Function

[Q53WG9_THET8] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Processes pre-crRNA into individual crRNA units, but may not actually undergo enzyme turnover, retaining the crRNA product. Generates a 2',3'-cyclic phosphodiester.[1] [2]

About this Structure

2y9h is a 16 chain structure with sequence from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

  • Sashital DG, Jinek M, Doudna JA. An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3. Nat Struct Mol Biol. 2011 Jun;18(6):680-7. Epub 2011 May 15. PMID:21572442 doi:10.1038/nsmb.2043
  1. ↑ Sashital DG, Jinek M, Doudna JA. An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3. Nat Struct Mol Biol. 2011 Jun;18(6):680-7. Epub 2011 May 15. PMID:21572442 doi:10.1038/nsmb.2043
  2. ↑ Gesner EM, Schellenberg MJ, Garside EL, George MM, Macmillan AM. Recognition and maturation of effector RNAs in a CRISPR interference pathway. Nat Struct Mol Biol. 2011 May 15. PMID:21572444 doi:10.1038/nsmb.2042

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