3nar

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{{STRUCTURE_3nar| PDB=3nar | SCENE= }}
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===Crystal structure of ZHX1 HD4 (zinc-fingers and homeoboxes protein 1, homeodomain 4)===
===Crystal structure of ZHX1 HD4 (zinc-fingers and homeoboxes protein 1, homeodomain 4)===
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{{ABSTRACT_PUBMED_20509910}}
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==Function==
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[[http://www.uniprot.org/uniprot/ZHX1_HUMAN ZHX1_HUMAN]] Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins.<ref>PMID:12237128</ref>
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{{ABSTRACT_PUBMED_20509910}}
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==About this Structure==
==About this Structure==
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3NAR is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NAR OCA].
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[[3nar]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NAR OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:20509910</ref><references group="xtra"/>
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<ref group="xtra">PMID:020509910</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bird, L E.]]
[[Category: Bird, L E.]]
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[[Category: Transcription]]
[[Category: Transcription]]
[[Category: Zhx1]]
[[Category: Zhx1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 7 08:43:13 2010''
 

Revision as of 20:59, 17 April 2013

Template:STRUCTURE 3nar

Contents

Crystal structure of ZHX1 HD4 (zinc-fingers and homeoboxes protein 1, homeodomain 4)

Template:ABSTRACT PUBMED 20509910

Function

[ZHX1_HUMAN] Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins.[1]

About this Structure

3nar is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Bird LE, Ren J, Nettleship JE, Folkers GE, Owens RJ, Stammers DK. Novel structural features in two ZHX homeodomains derived from a systematic study of single and multiple domains. BMC Struct Biol. 2010 May 28;10:13. PMID:20509910 doi:10.1186/1472-6807-10-13
  1. ↑ Yamada K, Kawata H, Matsuura K, Shou Z, Hirano S, Mizutani T, Yazawa T, Yoshino M, Sekiguchi T, Kajitani T, Miyamoto K. Functional analysis and the molecular dissection of zinc-fingers and homeoboxes 1 (ZHX1). Biochem Biophys Res Commun. 2002 Sep 20;297(2):368-74. PMID:12237128

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