3n1r
From Proteopedia
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{{STRUCTURE_3n1r| PDB=3n1r | SCENE= }} | {{STRUCTURE_3n1r| PDB=3n1r | SCENE= }} | ||
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===Crystal Structure of ShhN=== | ===Crystal Structure of ShhN=== | ||
| + | {{ABSTRACT_PUBMED_020519495}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/SHH_MOUSE SHH_MOUSE]] Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction (By similarity).<ref>PMID:7736596</ref> | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3n1r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N1R OCA]. | |
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:020519495</ref><references group="xtra"/><references/> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Kavran, J M.]] | [[Category: Kavran, J M.]] | ||
[[Category: Leahy, D J.]] | [[Category: Leahy, D J.]] | ||
[[Category: Binding site]] | [[Category: Binding site]] | ||
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[[Category: Cell adhesion molecule]] | [[Category: Cell adhesion molecule]] | ||
[[Category: Cell cycle protein]] | [[Category: Cell cycle protein]] | ||
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[[Category: Tertiary]] | [[Category: Tertiary]] | ||
[[Category: Tumor suppressor protein]] | [[Category: Tumor suppressor protein]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 2 08:41:01 2010'' | ||
Revision as of 21:02, 17 April 2013
Contents |
Crystal Structure of ShhN
Template:ABSTRACT PUBMED 020519495
Function
[SHH_MOUSE] Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction (By similarity).[1]
About this Structure
3n1r is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- Kavran JM, Ward MD, Oladosu OO, Mulepati S, Leahy DJ. All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner. J Biol Chem. 2010 Aug 6;285(32):24584-90. Epub 2010 Jun 1. PMID:20519495 doi:10.1074/jbc.M110.131680
- ↑ Roelink H, Porter JA, Chiang C, Tanabe Y, Chang DT, Beachy PA, Jessell TM. Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis. Cell. 1995 May 5;81(3):445-55. PMID:7736596
Categories: Mus musculus | Kavran, J M. | Leahy, D J. | Binding site | Cell adhesion molecule | Cell cycle protein | Cell line | Cell surface | Conserved sequence | Fibronectin | Hedgehog protein | Immunoglobulin g | Membrane glycoprotein | Membrane protein | Protein binding | Receptor | Sequence homology | Signal transduction | Tertiary | Tumor suppressor protein
