This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1qjk
From Proteopedia
| Line 29: | Line 29: | ||
[[Category: radical scavenger]] | [[Category: radical scavenger]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 16:00:32 2007'' |
Revision as of 13:55, 30 October 2007
|
METALLOTHIONEIN MTA FROM SEA URCHIN (ALPHA DOMAIN)
Overview
The three-dimensional structure of [(113)Cd7]-metallothionein-A (MTA) of, the sea urchin Strongylocentrotus purpuratus was determined by, homonuclear(1)H NMR experiments and heteronuclear [(1)H, (113)Cd]-correlation spectroscopy. MTA is composed of two globular, domains, an N-terminal four-metal domain of the amino acid residues 1 to, 36 and a Cd4Cys11cluster, and a C-terminal three-metal domain including, the amino acid residues 37 to 65 and a Cd3Cys9cluster. The structure, resembles the known mammalian and crustacean metallothioneins, but has a, significantly different connectivity pattern of the Cys-metal, co-ordination bonds and concomitantly contains novel local folds of some, polypeptide backbone segments. These differences can be related to, variations of the Cys sequence positions ... [(full description)]
About this Structure
1QJK is a [Single protein] structure of sequence from [Strongylocentrotus purpuratus] with CD as [ligand]. Structure known Active Site: CD4. Full crystallographic information is available from [OCA].
Reference
NMR structure of the sea urchin (Strongylocentrotus purpuratus) metallothionein MTA., Riek R, Precheur B, Wang Y, Mackay EA, Wider G, Guntert P, Liu A, Kagi JH, Wuthrich K, J Mol Biol. 1999 Aug 13;291(2):417-28. PMID:10438629
Page seeded by OCA on Tue Oct 30 16:00:32 2007
