3mv2
From Proteopedia
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{{STRUCTURE_3mv2| PDB=3mv2 | SCENE= }} | {{STRUCTURE_3mv2| PDB=3mv2 | SCENE= }} | ||
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===Crystal Structure of a-COP in Complex with e-COP=== | ===Crystal Structure of a-COP in Complex with e-COP=== | ||
| + | {{ABSTRACT_PUBMED_20534429}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/COPA_YEAST COPA_YEAST]] The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.<ref>PMID:17101773</ref> [[http://www.uniprot.org/uniprot/COPE_YEAST COPE_YEAST]] The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).<ref>PMID:9463377</ref> <ref>PMID:17101773</ref> | |
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==About this Structure== | ==About this Structure== | ||
| - | + | [[3mv2]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MV2 OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:020534429</ref><references group="xtra"/><references/> |
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Hoelz, A.]] | [[Category: Hoelz, A.]] | ||
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[[Category: Protein transport]] | [[Category: Protein transport]] | ||
[[Category: Vesicular membrane coat coat protein complex i]] | [[Category: Vesicular membrane coat coat protein complex i]] | ||
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Revision as of 21:10, 17 April 2013
Contents |
Crystal Structure of a-COP in Complex with e-COP
Template:ABSTRACT PUBMED 20534429
Function
[COPA_YEAST] The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.[1] [COPE_YEAST] The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).[2] [3]
About this Structure
3mv2 is a 6 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
- Hsia KC, Hoelz A. Crystal structure of alpha-COP in complex with epsilon-COP provides insight into the architecture of the COPI vesicular coat. Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11271-6. Epub 2010 Jun 3. PMID:20534429
- ↑ Gabriely G, Kama R, Gerst JE. Involvement of specific COPI subunits in protein sorting from the late endosome to the vacuole in yeast. Mol Cell Biol. 2007 Jan;27(2):526-40. Epub 2006 Nov 13. PMID:17101773 doi:MCB.00577-06
- ↑ Duden R, Kajikawa L, Wuestehube L, Schekman R. epsilon-COP is a structural component of coatomer that functions to stabilize alpha-COP. EMBO J. 1998 Feb 16;17(4):985-95. PMID:9463377 doi:10.1093/emboj/17.4.985
- ↑ Gabriely G, Kama R, Gerst JE. Involvement of specific COPI subunits in protein sorting from the late endosome to the vacuole in yeast. Mol Cell Biol. 2007 Jan;27(2):526-40. Epub 2006 Nov 13. PMID:17101773 doi:MCB.00577-06
