3ml6

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[[Image:3ml6.png|left|200px]]
 
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{{STRUCTURE_3ml6| PDB=3ml6 | SCENE= }}
{{STRUCTURE_3ml6| PDB=3ml6 | SCENE= }}
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===a complex between Dishevlled2 and clathrin adaptor AP-2===
===a complex between Dishevlled2 and clathrin adaptor AP-2===
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{{ABSTRACT_PUBMED_20947020}}
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==Function==
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[[http://www.uniprot.org/uniprot/DVL2_MOUSE DVL2_MOUSE]] Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes.<ref>PMID:17199046</ref> <ref>PMID:21189423</ref> <ref>PMID:20947020</ref>
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{{ABSTRACT_PUBMED_20947020}}
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==About this Structure==
==About this Structure==
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[[3ml6]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus,_rattus_norvegicus Mus musculus, rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ML6 OCA].
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[[3ml6]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ML6 OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:20947020</ref><references group="xtra"/>
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<ref group="xtra">PMID:020947020</ref><references group="xtra"/><references/>
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[[Category: Mus musculus, rattus norvegicus]]
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[[Category: Rattus norvegicus]]
[[Category: Harrison, S C.]]
[[Category: Harrison, S C.]]
[[Category: Kirchhausen, T L.]]
[[Category: Kirchhausen, T L.]]
[[Category: Xing, Y.]]
[[Category: Xing, Y.]]
[[Category: Yu, A.]]
[[Category: Yu, A.]]
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[[Category: Ap2]]
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[[Category: Dishevelled]]
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[[Category: Frizzled internalization]]
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[[Category: Non-canonical wnt signaling]]
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[[Category: Protein transport]]

Revision as of 21:15, 17 April 2013

Template:STRUCTURE 3ml6

Contents

a complex between Dishevlled2 and clathrin adaptor AP-2

Template:ABSTRACT PUBMED 20947020

Function

[DVL2_MOUSE] Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes.[1] [2] [3]

About this Structure

3ml6 is a 6 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  • Yu A, Xing Y, Harrison SC, Kirchhausen T. Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling. Structure. 2010 Oct 13;18(10):1311-20. PMID:20947020 doi:10.1016/j.str.2010.07.010
  1. ↑ Yu A, Rual JF, Tamai K, Harada Y, Vidal M, He X, Kirchhausen T. Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling. Dev Cell. 2007 Jan;12(1):129-41. PMID:17199046 doi:10.1016/j.devcel.2006.10.015
  2. ↑ Liu YT, Dan QJ, Wang J, Feng Y, Chen L, Liang J, Li Q, Lin SC, Wang ZX, Wu JW. Molecular basis of Wnt activation via the DIX domain protein Ccd1. J Biol Chem. 2011 Mar 11;286(10):8597-608. Epub 2010 Dec 28. PMID:21189423 doi:10.1074/jbc.M110.186742
  3. ↑ Yu A, Xing Y, Harrison SC, Kirchhausen T. Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling. Structure. 2010 Oct 13;18(10):1311-20. PMID:20947020 doi:10.1016/j.str.2010.07.010

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