We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.
3n7o
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | {{Seed}} | ||
| - | [[Image:3n7o.png|left|200px]] | ||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, containing "STRUCTURE_3n7o", creates the "Structure Box" on the page. | ||
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| - | or leave the SCENE parameter empty for the default display. | ||
| - | --> | ||
{{STRUCTURE_3n7o| PDB=3n7o | SCENE= }} | {{STRUCTURE_3n7o| PDB=3n7o | SCENE= }} | ||
| - | |||
===X-ray structure of human chymase in complex with small molecule inhibitor.=== | ===X-ray structure of human chymase in complex with small molecule inhibitor.=== | ||
| + | {{ABSTRACT_PUBMED_20599788}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/CMA1_HUMAN CMA1_HUMAN]] Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3n7o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N7O OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:020599788</ref><references group="xtra"/><references/> |
[[Category: Chymase]] | [[Category: Chymase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| Line 37: | Line 24: | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Serine protease]] | [[Category: Serine protease]] | ||
| - | |||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 1 09:24:47 2010'' | ||
Revision as of 21:15, 17 April 2013
Contents |
X-ray structure of human chymase in complex with small molecule inhibitor.
Template:ABSTRACT PUBMED 20599788
Function
[CMA1_HUMAN] Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
About this Structure
3n7o is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Kervinen J, Crysler C, Bayoumy S, Abad MC, Spurlino J, Deckman I, Greco MN, Maryanoff BE, de Garavilla L. Potency variation of small-molecule chymase inhibitors across species. Biochem Pharmacol. 2010 Oct 1;80(7):1033-41. Epub 2010 Jun 23. PMID:20599788 doi:10.1016/j.bcp.2010.06.014
