3n7s

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{{STRUCTURE_3n7s| PDB=3n7s | SCENE= }}
{{STRUCTURE_3n7s| PDB=3n7s | SCENE= }}
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===Crystal structure of the ectodomain complex of the CGRP receptor, a Class-B GPCR, reveals the site of drug antagonism===
===Crystal structure of the ectodomain complex of the CGRP receptor, a Class-B GPCR, reveals the site of drug antagonism===
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{{ABSTRACT_PUBMED_20826335}}
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==Function==
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[[http://www.uniprot.org/uniprot/RAMP1_HUMAN RAMP1_HUMAN]] Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.<ref>PMID:9620797</ref>
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{{ABSTRACT_PUBMED_20826335}}
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==About this Structure==
==About this Structure==
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3N7S is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N7S OCA].
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[[3n7s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N7S OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:20826335</ref><references group="xtra"/>
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<ref group="xtra">PMID:020826335</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Haar, E Ter.]]
[[Category: Haar, E Ter.]]
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[[Category: Olcegepant]]
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[[Category: Telcagepant]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 14:23:42 2010''
 

Revision as of 21:16, 17 April 2013

Template:STRUCTURE 3n7s

Contents

Crystal structure of the ectodomain complex of the CGRP receptor, a Class-B GPCR, reveals the site of drug antagonism

Template:ABSTRACT PUBMED 20826335

Function

[RAMP1_HUMAN] Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.[1]

About this Structure

3n7s is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • ter Haar E, Koth CM, Abdul-Manan N, Swenson L, Coll JT, Lippke JA, Lepre CA, Garcia-Guzman M, Moore JM. Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism. Structure. 2010 Sep 8;18(9):1083-93. PMID:20826335 doi:10.1016/j.str.2010.05.014
  1. ↑ McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature. 1998 May 28;393(6683):333-9. PMID:9620797 doi:10.1038/30666

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