1qko
From Proteopedia
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[[Category: retinal protein]] | [[Category: retinal protein]] | ||
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Revision as of 13:56, 30 October 2007
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HIGH RESOLUTION X-RAY STRUCTURE OF AN EARLY INTERMEDIATE IN THE BACTERIORHODOPSIN PHOTOCYCLE
Overview
Bacteriorhodopsin is the simplest known photon-driven proton pump and as, such provides a model for the study of a basic function in bioenergetics., Its seven transmembrane helices encompass a proton translocation pathway, containing the chromophore, a retinal molecule covalently bound to lysine, 216 through a protonated Schiff base, and a series of proton donors and, acceptors. Photoisomerization of the all-trans retinal to the 13-cis, configuration initiates the vectorial translocation of a proton from the, Schiff base, the primary proton donor, to the extracellular side, followed, by reprotonation of the Schiff base from the cytoplasm. Here we describe, the high-resolution X-ray structure of an early intermediate in the, photocycle of bacteriorhodopsin, which is formed directly after, ... [(full description)]
About this Structure
1QKO is a [Single protein] structure of sequence from [Halobacterium salinarum] with RET as [ligand]. Structure known Active Site: SFF. Full crystallographic information is available from [OCA].
Reference
High-resolution X-ray structure of an early intermediate in the bacteriorhodopsin photocycle., Edman K, Nollert P, Royant A, Belrhali H, Pebay-Peyroula E, Hajdu J, Neutze R, Landau EM, Nature. 1999 Oct 21;401(6755):822-6. PMID:10548112
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