4j36

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{{STRUCTURE_4j36| PDB=4j36 | SCENE= }}
{{STRUCTURE_4j36| PDB=4j36 | SCENE= }}
===Cocrystal Structure of kynurenine 3-monooxygenase in complex with UPF 648 inhibitor(KMO-394UPF)===
===Cocrystal Structure of kynurenine 3-monooxygenase in complex with UPF 648 inhibitor(KMO-394UPF)===
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{{ABSTRACT_PUBMED_23575632}}
==Function==
==Function==

Revision as of 10:26, 24 April 2013

Template:STRUCTURE 4j36

Contents

Cocrystal Structure of kynurenine 3-monooxygenase in complex with UPF 648 inhibitor(KMO-394UPF)

Template:ABSTRACT PUBMED 23575632

Function

[KMO_YEAST] Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.[1] [2]

About this Structure

4j36 is a 2 chain structure with sequence from Saccharomyces cerevisiae s288c. Full crystallographic information is available from OCA.

Reference

  1. ↑ Panozzo C, Nawara M, Suski C, Kucharczyka R, Skoneczny M, Becam AM, Rytka J, Herbert CJ. Aerobic and anaerobic NAD+ metabolism in Saccharomyces cerevisiae. FEBS Lett. 2002 Apr 24;517(1-3):97-102. PMID:12062417
  2. ↑ Giorgini F, Guidetti P, Nguyen Q, Bennett SC, Muchowski PJ. A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease. Nat Genet. 2005 May;37(5):526-31. Epub 2005 Apr 3. PMID:15806102 doi:ng1542

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OCA

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