4g4r
From Proteopedia
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| - | [[Image:4g4r.png|left|200px]] | ||
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{{STRUCTURE_4g4r| PDB=4g4r | SCENE= }} | {{STRUCTURE_4g4r| PDB=4g4r | SCENE= }} | ||
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===MutM containing F114A mutation bound to oxoG-containing DNA=== | ===MutM containing F114A mutation bound to oxoG-containing DNA=== | ||
| + | {{ABSTRACT_PUBMED_23404556}} | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/P84131_GEOSE P84131_GEOSE]] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).[HAMAP-Rule:MF_00103][SAAS:SAAS020629_004_120556] | ||
==About this Structure== | ==About this Structure== | ||
Revision as of 10:27, 24 April 2013
MutM containing F114A mutation bound to oxoG-containing DNA
Template:ABSTRACT PUBMED 23404556
Function
[P84131_GEOSE] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).[HAMAP-Rule:MF_00103][SAAS:SAAS020629_004_120556]
About this Structure
4g4r is a 3 chain structure with sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.
