2w8n
From Proteopedia
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{{STRUCTURE_2w8n| PDB=2w8n | SCENE= }} | {{STRUCTURE_2w8n| PDB=2w8n | SCENE= }} | ||
| - | === | + | ===The crystal structure of the oxidized form of human SSADH=== |
{{ABSTRACT_PUBMED_19300440}} | {{ABSTRACT_PUBMED_19300440}} | ||
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==Function== | ==Function== | ||
| - | [[http://www.uniprot.org/uniprot/SSDH_HUMAN SSDH_HUMAN]] Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).<ref>PMID:19300440</ref> | + | [[http://www.uniprot.org/uniprot/SSDH_HUMAN SSDH_HUMAN]] Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).<ref>PMID:19300440</ref> |
==About this Structure== | ==About this Structure== | ||
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<ref group="xtra">PMID:019300440</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:019300440</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Succinate-semialdehyde dehydrogenase]] | ||
[[Category: Kim, K J.]] | [[Category: Kim, K J.]] | ||
[[Category: Kim, Y G.]] | [[Category: Kim, Y G.]] | ||
| - | [[Category: Dehydrogenase]] | ||
[[Category: Disease mutation]] | [[Category: Disease mutation]] | ||
[[Category: Mitochondria]] | [[Category: Mitochondria]] | ||
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[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
[[Category: Ssa]] | [[Category: Ssa]] | ||
| - | [[Category: Ssadh]] | ||
[[Category: Transit peptide]] | [[Category: Transit peptide]] | ||
Revision as of 10:36, 24 April 2013
Contents |
The crystal structure of the oxidized form of human SSADH
Template:ABSTRACT PUBMED 19300440
Disease
[SSDH_HUMAN] Defects in ALDH5A1 are the cause of succinate semialdehyde dehydrogenase deficiency (SSADH deficiency) [MIM:271980]. SSADH deficiency is a rare inborn error in the metabolism of 4-aminobutyric acid (GABA) which leads to accumulation of 4-hydroxybutyric acid in physiologic fluids of patients. The disease is characterized by severe ataxia and by mildly retarded psychomotor development.
Function
[SSDH_HUMAN] Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).[1]
About this Structure
2w8n is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Kim YG, Lee S, Kwon OS, Park SY, Lee SJ, Park BJ, Kim KJ. Redox-switch modulation of human SSADH by dynamic catalytic loop. EMBO J. 2009 Apr 8;28(7):959-68. Epub 2009 Mar 19. PMID:19300440 doi:10.1038/emboj.2009.40
- ↑ Kim YG, Lee S, Kwon OS, Park SY, Lee SJ, Park BJ, Kim KJ. Redox-switch modulation of human SSADH by dynamic catalytic loop. EMBO J. 2009 Apr 8;28(7):959-68. Epub 2009 Mar 19. PMID:19300440 doi:10.1038/emboj.2009.40
Categories: Homo sapiens | Kim, K J. | Kim, Y G. | Disease mutation | Mitochondria | Mitochondrion | Nad | Oxidoreductase | Ssa | Transit peptide
