4b94

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'''Unreleased structure'''
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{{STRUCTURE_4b94| PDB=4b94 | SCENE= }}
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===Crystal structure of human Mps1 TPR domain===
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{{ABSTRACT_PUBMED_23569217}}
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The entry 4b94 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
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Authors: Littler, D., von Castelmur, E., De Marco, V., Perrakis, A.
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==About this Structure==
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[[4b94]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B94 OCA].
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Description: Crystal structure of human Mps1 TPR domain
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Dual-specificity kinase]]
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[[Category: Homo sapiens]]
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[[Category: Castelmur, E von.]]
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[[Category: Littler, D.]]
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[[Category: Marco, V De.]]
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[[Category: Perrakis, A.]]
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[[Category: Kinetochore]]
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[[Category: Mitosis]]
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[[Category: Transferase]]

Revision as of 11:17, 24 April 2013

Template:STRUCTURE 4b94

Contents

Crystal structure of human Mps1 TPR domain

Template:ABSTRACT PUBMED 23569217

Function

[TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.[1]

About this Structure

4b94 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Jelluma N, Brenkman AB, van den Broek NJ, Cruijsen CW, van Osch MH, Lens SM, Medema RH, Kops GJ. Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment. Cell. 2008 Jan 25;132(2):233-46. doi: 10.1016/j.cell.2007.11.046. PMID:18243099 doi:10.1016/j.cell.2007.11.046

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