4i03

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'''Unreleased structure'''
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{{STRUCTURE_4i03| PDB=4i03 | SCENE= }}
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===Human MMP12 in complex with a PEG-linked bifunctional L-glutamate motif inhibitor===
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{{ABSTRACT_PUBMED_23567804}}
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The entry 4i03 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN]] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
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Authors: Stura, E.A., Vera, L., Devel, L., Cassar-Lajeunesse, E., Dive, V.
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==About this Structure==
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[[4i03]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I03 OCA].
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Description: Human MMP12 in complex with a PEG-linked bifunctional L-glutamate motif inhibitor
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[[Category: Homo sapiens]]
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[[Category: Macrophage elastase]]
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[[Category: Cassar-Lajeunesse, E.]]
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[[Category: Devel, L.]]
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[[Category: Dive, V.]]
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[[Category: Stura, E A.]]
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[[Category: Vera, L.]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Metzincin]]
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[[Category: Selective carboxylate based mmp-12 bifunctional inhibitor]]
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[[Category: Zinc protease]]

Revision as of 11:20, 24 April 2013

Template:STRUCTURE 4i03

Human MMP12 in complex with a PEG-linked bifunctional L-glutamate motif inhibitor

Template:ABSTRACT PUBMED 23567804

Function

[MMP12_HUMAN] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.

About this Structure

4i03 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

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OCA

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