2f3k
From Proteopedia
| Line 4: | Line 4: | ||
==Overview== | ==Overview== | ||
| - | In our previous crystallographic studies of human immunodeficiency virus | + | In our previous crystallographic studies of human immunodeficiency virus type 1 (HIV-1) protease-substrate complexes, we described a conserved "envelope" that appears to be important for substrate recognition and the selection of drug-resistant mutations. In this study, the complex of HIV-1 protease with the inhibitor RO1 was determined and comparison with the substrate envelope provides a rationale for mutational patterns. |
==About this Structure== | ==About this Structure== | ||
| Line 16: | Line 16: | ||
[[Category: Cammack, N.]] | [[Category: Cammack, N.]] | ||
[[Category: Heilek-Snyder, G.]] | [[Category: Heilek-Snyder, G.]] | ||
| - | [[Category: King, N | + | [[Category: King, N M.]] |
| - | [[Category: Nalivaika, E | + | [[Category: Nalivaika, E A.]] |
[[Category: Prabu-Jeyabalan, M.]] | [[Category: Prabu-Jeyabalan, M.]] | ||
| - | [[Category: Schiffer, C | + | [[Category: Schiffer, C A.]] |
[[Category: PO4]] | [[Category: PO4]] | ||
[[Category: RO1]] | [[Category: RO1]] | ||
| Line 27: | Line 27: | ||
[[Category: substrate envelope]] | [[Category: substrate envelope]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:17:23 2008'' |
Revision as of 15:17, 21 February 2008
|
Substrate envelope and drug resistance: crystal structure of r01 in complex with wild-type hiv-1 protease
Overview
In our previous crystallographic studies of human immunodeficiency virus type 1 (HIV-1) protease-substrate complexes, we described a conserved "envelope" that appears to be important for substrate recognition and the selection of drug-resistant mutations. In this study, the complex of HIV-1 protease with the inhibitor RO1 was determined and comparison with the substrate envelope provides a rationale for mutational patterns.
About this Structure
2F3K is a Single protein structure of sequence from Human immunodeficiency virus 1 with and as ligands. Active as HIV-1 retropepsin, with EC number 3.4.23.16 Full crystallographic information is available from OCA.
Reference
Substrate envelope and drug resistance: crystal structure of RO1 in complex with wild-type human immunodeficiency virus type 1 protease., Prabu-Jeyabalan M, King NM, Nalivaika EA, Heilek-Snyder G, Cammack N, Schiffer CA, Antimicrob Agents Chemother. 2006 Apr;50(4):1518-21. PMID:16569872
Page seeded by OCA on Thu Feb 21 17:17:23 2008
