2f44
From Proteopedia
(New page: 200px<br /><applet load="2f44" size="450" color="white" frame="true" align="right" spinBox="true" caption="2f44, resolution 2.4Å" /> '''Crystal Structure of ...) |
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| - | [[Image:2f44.gif|left|200px]]<br /><applet load="2f44" size=" | + | [[Image:2f44.gif|left|200px]]<br /><applet load="2f44" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2f44, resolution 2.4Å" /> | caption="2f44, resolution 2.4Å" /> | ||
'''Crystal Structure of the Zinc-bound Shank SAM domain'''<br /> | '''Crystal Structure of the Zinc-bound Shank SAM domain'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The postsynaptic density (PSD) is a complex assembly of proteins | + | The postsynaptic density (PSD) is a complex assembly of proteins associated with the postsynaptic membrane that organizes neurotransmitter receptors, signaling pathways, and regulatory elements within a cytoskeletal matrix. Here we show that the sterile alpha motif domain of rat Shank3/ProSAP2, a master scaffolding protein located deep within the PSD, can form large sheets composed of helical fibers stacked side by side. Zn2+, which is found in high concentrations in the PSD, binds tightly to Shank3 and may regulate assembly. Sheets of the Shank protein could form a platform for the construction of the PSD complex. |
==About this Structure== | ==About this Structure== | ||
| - | 2F44 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with ZN and CL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 2F44 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=CL:'>CL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F44 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Baron, M | + | [[Category: Baron, M K.]] |
| - | [[Category: Bowie, J | + | [[Category: Bowie, J U.]] |
[[Category: Faham, S.]] | [[Category: Faham, S.]] | ||
[[Category: CL]] | [[Category: CL]] | ||
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[[Category: zinc]] | [[Category: zinc]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:17:30 2008'' |
Revision as of 15:17, 21 February 2008
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Crystal Structure of the Zinc-bound Shank SAM domain
Overview
The postsynaptic density (PSD) is a complex assembly of proteins associated with the postsynaptic membrane that organizes neurotransmitter receptors, signaling pathways, and regulatory elements within a cytoskeletal matrix. Here we show that the sterile alpha motif domain of rat Shank3/ProSAP2, a master scaffolding protein located deep within the PSD, can form large sheets composed of helical fibers stacked side by side. Zn2+, which is found in high concentrations in the PSD, binds tightly to Shank3 and may regulate assembly. Sheets of the Shank protein could form a platform for the construction of the PSD complex.
About this Structure
2F44 is a Single protein structure of sequence from Rattus norvegicus with and as ligands. Full crystallographic information is available from OCA.
Reference
An architectural framework that may lie at the core of the postsynaptic density., Baron MK, Boeckers TM, Vaida B, Faham S, Gingery M, Sawaya MR, Salyer D, Gundelfinger ED, Bowie JU, Science. 2006 Jan 27;311(5760):531-5. PMID:16439662
Page seeded by OCA on Thu Feb 21 17:17:30 2008
Categories: Rattus norvegicus | Single protein | Baron, M K. | Bowie, J U. | Faham, S. | CL | ZN | Post-synaptic density | Sam domain | Scaffolding protein | Shank | Zinc
