4bgx
From Proteopedia
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| - | ' | + | {{STRUCTURE_4bgx| PDB=4bgx | SCENE= }} |
| + | ===H5 (VN1194) Influenza Virus Haemagglutinin in Complex with Human Receptor Analogue 6'-SLN=== | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/Q6DQ34_9INFA Q6DQ34_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643] | ||
| - | + | ==About this Structure== | |
| - | + | [[4bgx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Unidentified_influenza_virus Unidentified influenza virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BGX OCA]. | |
| - | + | [[Category: Unidentified influenza virus]] | |
| + | [[Category: Collins, P J.]] | ||
| + | [[Category: Coombs, P.]] | ||
| + | [[Category: Gamblin, S J.]] | ||
| + | [[Category: Kawaoka, Y.]] | ||
| + | [[Category: Liu, J.]] | ||
| + | [[Category: Locher, K.]] | ||
| + | [[Category: Martin, S R.]] | ||
| + | [[Category: McCauley, J W.]] | ||
| + | [[Category: Skehel, J J.]] | ||
| + | [[Category: Walker, P A.]] | ||
| + | [[Category: Xiao, H.]] | ||
| + | [[Category: Xiong, X.]] | ||
| + | [[Category: Bird flu]] | ||
| + | [[Category: N-glycosylation]] | ||
| + | [[Category: Viral protein]] | ||
| + | [[Category: Virus receptor]] | ||
Revision as of 11:26, 24 April 2013
H5 (VN1194) Influenza Virus Haemagglutinin in Complex with Human Receptor Analogue 6'-SLN
Function
[Q6DQ34_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]
About this Structure
4bgx is a 2 chain structure with sequence from Unidentified influenza virus. Full crystallographic information is available from OCA.
