3nis
From Proteopedia
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m (Protected "3nis" [edit=sysop:move=sysop]) |
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Contents |
The structure of UBR box (native2)
Template:ABSTRACT PUBMED 20835240
Function
[UBR1_YEAST] Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
About this Structure
3nis is a 4 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
See Also
Reference
- Choi WS, Jeong BC, Joo YJ, Lee MR, Kim J, Eck MJ, Song HK. Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases. Nat Struct Mol Biol. 2010 Sep 12. PMID:20835240 doi:10.1038/nsmb.1907