3o8a
From Proteopedia
(Difference between revisions)
m (Protected "3o8a" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:3o8a.png|left|200px]] | ||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, containing "STRUCTURE_3o8a", creates the "Structure Box" on the page. | ||
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| - | or leave the SCENE parameter empty for the default display. | ||
| - | --> | ||
{{STRUCTURE_3o8a| PDB=3o8a | SCENE= }} | {{STRUCTURE_3o8a| PDB=3o8a | SCENE= }} | ||
| - | |||
===Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with novel Inhibitor Genz667348=== | ===Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with novel Inhibitor Genz667348=== | ||
| + | {{ABSTRACT_PUBMED_20702404}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/PYRD_PLAF7 PYRD_PLAF7]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
==About this Structure== | ==About this Structure== | ||
[[3o8a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O8A OCA]. | [[3o8a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O8A OCA]. | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Dihydroorotate dehydrogenase|Dihydroorotate dehydrogenase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:020702404</ref><references group="xtra"/><references/> |
[[Category: Dihydroorotate dehydrogenase]] | [[Category: Dihydroorotate dehydrogenase]] | ||
[[Category: Plasmodium falciparum]] | [[Category: Plasmodium falciparum]] | ||
| Line 28: | Line 19: | ||
[[Category: Deng, X.]] | [[Category: Deng, X.]] | ||
[[Category: Phillips, M A.]] | [[Category: Phillips, M A.]] | ||
| + | [[Category: Alpha beta fold]] | ||
| + | [[Category: Dihydroorotate dehydrogenase]] | ||
| + | [[Category: Fad]] | ||
| + | [[Category: Flavoprotein]] | ||
| + | [[Category: Genz667348]] | ||
| + | [[Category: Mitochondrion inner membrane]] | ||
| + | [[Category: Oxidoreductase]] | ||
| + | [[Category: Pyrimidine biosynthesis]] | ||
Revision as of 11:44, 24 April 2013
Contents |
Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with novel Inhibitor Genz667348
Template:ABSTRACT PUBMED 20702404
Function
[PYRD_PLAF7] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
About this Structure
3o8a is a 1 chain structure with sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.
See Also
Reference
- Booker ML, Bastos CM, Kramer ML, Barker RH Jr, Skerlj R, Sidhu AB, Deng X, Celatka C, Cortese JF, Guerrero Bravo JE, Crespo Llado KN, Serrano AE, Angulo-Barturen I, Jimenez-Diaz MB, Viera S, Garuti H, Wittlin S, Papastogiannidis P, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman B, Goldsmith EJ, Phillips MA, Munoz B, Wirth DF, Klinger JD, Wiegand R, Sybertz E. Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model. J Biol Chem. 2010 Oct 22;285(43):33054-64. Epub 2010 Aug 11. PMID:20702404 doi:10.1074/jbc.M110.162081
