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3o0v
From Proteopedia
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{{STRUCTURE_3o0v| PDB=3o0v | SCENE= }} | {{STRUCTURE_3o0v| PDB=3o0v | SCENE= }} | ||
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===Crystal structure of the calreticulin lectin domain=== | ===Crystal structure of the calreticulin lectin domain=== | ||
| + | {{ABSTRACT_PUBMED_20880849}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/Q3TVD2_MOUSE Q3TVD2_MOUSE]] Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).<ref>PMID:20880849</ref> <ref>PMID:21652723</ref> | |
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==About this Structure== | ==About this Structure== | ||
| - | + | [[3o0v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O0V OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:020880849</ref><references group="xtra"/><references/> |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Gehring, K.]] | [[Category: Gehring, K.]] | ||
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[[Category: Chaperone]] | [[Category: Chaperone]] | ||
[[Category: Jelly roll fold]] | [[Category: Jelly roll fold]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 22 09:22:18 2010'' | ||
Revision as of 11:47, 24 April 2013
Contents |
Crystal structure of the calreticulin lectin domain
Template:ABSTRACT PUBMED 20880849
Function
[Q3TVD2_MOUSE] Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).[1] [2]
About this Structure
3o0v is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- Kozlov G, Pocanschi CL, Rosenauer A, Bastos-Aristizabal S, Gorelik A, Williams DB, Gehring K. Structural basis of carbohydrate recognition by calreticulin. J Biol Chem. 2010 Dec 3;285(49):38612-20. Epub 2010 Sep 29. PMID:20880849 doi:10.1074/jbc.M110.168294
- ↑ Kozlov G, Pocanschi CL, Rosenauer A, Bastos-Aristizabal S, Gorelik A, Williams DB, Gehring K. Structural basis of carbohydrate recognition by calreticulin. J Biol Chem. 2010 Dec 3;285(49):38612-20. Epub 2010 Sep 29. PMID:20880849 doi:10.1074/jbc.M110.168294
- ↑ Pocanschi CL, Kozlov G, Brockmeier U, Brockmeier A, Williams DB, Gehring K. Structural and functional relationships between the lectin and arm domains of calreticulin. J Biol Chem. 2011 Jun 7. PMID:21652723 doi:10.1074/jbc.M111.258467
