3ngq

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{{STRUCTURE_3ngq| PDB=3ngq | SCENE= }}
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===Crystal structure of the human CNOT6L nuclease domain===
===Crystal structure of the human CNOT6L nuclease domain===
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{{ABSTRACT_PUBMED_20628353}}
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==Function==
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[[http://www.uniprot.org/uniprot/CNO6L_HUMAN CNO6L_HUMAN]] Plays a role in the deadenylation of mRNAs in the cytoplasm. Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA.<ref>PMID:17452450</ref>
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{{ABSTRACT_PUBMED_20628353}}
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==About this Structure==
==About this Structure==
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3NGQ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NGQ OCA].
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[[3ngq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NGQ OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:20628353</ref><references group="xtra"/>
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<ref group="xtra">PMID:020628353</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bartlam, M.]]
[[Category: Bartlam, M.]]
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[[Category: Alpha/beta sandwich fold]]
[[Category: Alpha/beta sandwich fold]]
[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 28 12:42:08 2010''
 

Revision as of 11:51, 24 April 2013

Template:STRUCTURE 3ngq

Contents

Crystal structure of the human CNOT6L nuclease domain

Template:ABSTRACT PUBMED 20628353

Function

[CNO6L_HUMAN] Plays a role in the deadenylation of mRNAs in the cytoplasm. Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA.[1]

About this Structure

3ngq is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Wang H, Morita M, Yang X, Suzuki T, Yang W, Wang J, Ito K, Wang Q, Zhao C, Bartlam M, Yamamoto T, Rao Z. Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity. EMBO J. 2010 Aug 4;29(15):2566-76. Epub 2010 Jul 13. PMID:20628353 doi:10.1038/emboj.2010.152
  1. ↑ Morita M, Suzuki T, Nakamura T, Yokoyama K, Miyasaka T, Yamamoto T. Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth. Mol Cell Biol. 2007 Jul;27(13):4980-90. Epub 2007 Apr 23. PMID:17452450 doi:MCB.02304-06

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