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3nt7
From Proteopedia
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{{STRUCTURE_3nt7| PDB=3nt7 | SCENE= }} | {{STRUCTURE_3nt7| PDB=3nt7 | SCENE= }} | ||
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===Crystal Structure of Vaccinia Virus Uracil DNA Glycosylase R187V Mutant=== | ===Crystal Structure of Vaccinia Virus Uracil DNA Glycosylase R187V Mutant=== | ||
| + | {{ABSTRACT_PUBMED_20861259}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/UNG_VACCA UNG_VACCA]] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. Also part of a heterodimeric processivity factor which potentiates the DNA polymerase activity. Binds to DNA. | |
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:020861259</ref><references group="xtra"/> | + | <ref group="xtra">PMID:020861259</ref><references group="xtra"/><references/> |
[[Category: Uracil-DNA glycosylase]] | [[Category: Uracil-DNA glycosylase]] | ||
[[Category: Vaccinia virus]] | [[Category: Vaccinia virus]] | ||
[[Category: Chattopadhyay, D.]] | [[Category: Chattopadhyay, D.]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Uracil-dna glycosylase fold]] | ||
Revision as of 11:54, 24 April 2013
Contents |
Crystal Structure of Vaccinia Virus Uracil DNA Glycosylase R187V Mutant
Template:ABSTRACT PUBMED 20861259
Function
[UNG_VACCA] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. Also part of a heterodimeric processivity factor which potentiates the DNA polymerase activity. Binds to DNA.
About this Structure
3nt7 is a 2 chain structure with sequence from Vaccinia virus. Full crystallographic information is available from OCA.
Reference
- Druck Shudofsky AM, Silverman JE, Chattopadhyay D, Ricciardi RP. Vaccinia virus D4 mutants defective in processive DNA synthesis retain binding to A20 and DNA. J Virol. 2010 Dec;84(23):12325-35. Epub 2010 Sep 22. PMID:20861259 doi:10.1128/JVI.01435-10
