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3nds

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[[Image:3nds.png|left|200px]]
 
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{{STRUCTURE_3nds| PDB=3nds | SCENE= }}
{{STRUCTURE_3nds| PDB=3nds | SCENE= }}
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===Crystal structure of engineered Naja Nigricollis toxin alpha===
===Crystal structure of engineered Naja Nigricollis toxin alpha===
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{{ABSTRACT_PUBMED_20804768}}
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==Function==
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[[http://www.uniprot.org/uniprot/NXS1_NAJPA NXS1_NAJPA]] Binds with high affinity to muscular nicotinic acetylcholine receptors (nAChRs), and with low affinity to neuronal alpha-7 nAChRs. Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site.<ref>PMID:9305882</ref>
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{{ABSTRACT_PUBMED_20804768}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:20804768</ref><references group="xtra"/>
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<ref group="xtra">PMID:020804768</ref><references group="xtra"/><references/>
[[Category: Drevet, P.]]
[[Category: Drevet, P.]]
[[Category: Gallopin, M.]]
[[Category: Gallopin, M.]]
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[[Category: Stura, E A.]]
[[Category: Stura, E A.]]
[[Category: Vandame, M.]]
[[Category: Vandame, M.]]
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[[Category: Disulfide pairing]]
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[[Category: Folding intermediate]]
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[[Category: Snake toxin]]
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[[Category: Three finger toxin fold]]
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[[Category: Toxin]]
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[[Category: Venom]]

Revision as of 11:57, 24 April 2013

Template:STRUCTURE 3nds

Contents

Crystal structure of engineered Naja Nigricollis toxin alpha

Template:ABSTRACT PUBMED 20804768

Function

[NXS1_NAJPA] Binds with high affinity to muscular nicotinic acetylcholine receptors (nAChRs), and with low affinity to neuronal alpha-7 nAChRs. Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site.[1]

About this Structure

3nds is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Gross G, Gallopin M, Vandame M, Couprie J, Stura E, Zinn-Justin S, Drevet P. Conformational exchange is critical for the productivity of an oxidative folding intermediate with buried free cysteines. J Mol Biol. 2010 Oct 22;403(2):299-312. Epub 2010 Sep 8. PMID:20804768 doi:10.1016/j.jmb.2010.07.048
  1. ↑ Servent D, Winckler-Dietrich V, Hu HY, Kessler P, Drevet P, Bertrand D, Menez A. Only snake curaremimetic toxins with a fifth disulfide bond have high affinity for the neuronal alpha7 nicotinic receptor. J Biol Chem. 1997 Sep 26;272(39):24279-86. PMID:9305882

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