3nds

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3nds" [edit=sysop:move=sysop])
Line 1: Line 1:
-
[[Image:3nds.png|left|200px]]
 
- 
-
<!--
 
-
The line below this paragraph, containing "STRUCTURE_3nds", creates the "Structure Box" on the page.
 
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
 
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
 
-
or leave the SCENE parameter empty for the default display.
 
-
-->
 
{{STRUCTURE_3nds| PDB=3nds | SCENE= }}
{{STRUCTURE_3nds| PDB=3nds | SCENE= }}
- 
===Crystal structure of engineered Naja Nigricollis toxin alpha===
===Crystal structure of engineered Naja Nigricollis toxin alpha===
 +
{{ABSTRACT_PUBMED_20804768}}
-
 
+
==Function==
-
<!--
+
[[http://www.uniprot.org/uniprot/NXS1_NAJPA NXS1_NAJPA]] Binds with high affinity to muscular nicotinic acetylcholine receptors (nAChRs), and with low affinity to neuronal alpha-7 nAChRs. Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site.<ref>PMID:9305882</ref>
-
The line below this paragraph, {{ABSTRACT_PUBMED_20804768}}, adds the Publication Abstract to the page
+
-
(as it appears on PubMed at http://www.pubmed.gov), where 20804768 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_20804768}}
+
==About this Structure==
==About this Structure==
Line 22: Line 10:
==Reference==
==Reference==
-
<ref group="xtra">PMID:20804768</ref><references group="xtra"/>
+
<ref group="xtra">PMID:020804768</ref><references group="xtra"/><references/>
[[Category: Drevet, P.]]
[[Category: Drevet, P.]]
[[Category: Gallopin, M.]]
[[Category: Gallopin, M.]]
Line 28: Line 16:
[[Category: Stura, E A.]]
[[Category: Stura, E A.]]
[[Category: Vandame, M.]]
[[Category: Vandame, M.]]
 +
[[Category: Disulfide pairing]]
 +
[[Category: Folding intermediate]]
 +
[[Category: Snake toxin]]
 +
[[Category: Three finger toxin fold]]
 +
[[Category: Toxin]]
 +
[[Category: Venom]]

Revision as of 11:57, 24 April 2013

Template:STRUCTURE 3nds

Contents

Crystal structure of engineered Naja Nigricollis toxin alpha

Template:ABSTRACT PUBMED 20804768

Function

[NXS1_NAJPA] Binds with high affinity to muscular nicotinic acetylcholine receptors (nAChRs), and with low affinity to neuronal alpha-7 nAChRs. Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site.[1]

About this Structure

3nds is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Gross G, Gallopin M, Vandame M, Couprie J, Stura E, Zinn-Justin S, Drevet P. Conformational exchange is critical for the productivity of an oxidative folding intermediate with buried free cysteines. J Mol Biol. 2010 Oct 22;403(2):299-312. Epub 2010 Sep 8. PMID:20804768 doi:10.1016/j.jmb.2010.07.048
  1. ↑ Servent D, Winckler-Dietrich V, Hu HY, Kessler P, Drevet P, Bertrand D, Menez A. Only snake curaremimetic toxins with a fifth disulfide bond have high affinity for the neuronal alpha7 nicotinic receptor. J Biol Chem. 1997 Sep 26;272(39):24279-86. PMID:9305882

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3nds"
Personal tools