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3o76
From Proteopedia
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{{STRUCTURE_3o76| PDB=3o76 | SCENE= }} | {{STRUCTURE_3o76| PDB=3o76 | SCENE= }} | ||
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===1.8 Angstroms molecular structure of mouse liver glutathione S-transferase mutant C47A complexed with S-(P-nitrobenzyl)glutathione=== | ===1.8 Angstroms molecular structure of mouse liver glutathione S-transferase mutant C47A complexed with S-(P-nitrobenzyl)glutathione=== | ||
| + | {{ABSTRACT_PUBMED_21134126}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/GSTP1_MOUSE GSTP1_MOUSE]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Can metabolize 1-chloro-2,4-dinitrobenzene. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity). | |
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==About this Structure== | ==About this Structure== | ||
[[3o76]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O76 OCA]. | [[3o76]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O76 OCA]. | ||
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| + | ==See Also== | ||
| + | *[[Glutathione S-transferase|Glutathione S-transferase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:021134126</ref><references group="xtra"/> | + | <ref group="xtra">PMID:021134126</ref><references group="xtra"/><references/> |
[[Category: Glutathione transferase]] | [[Category: Glutathione transferase]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
Revision as of 12:10, 24 April 2013
Contents |
1.8 Angstroms molecular structure of mouse liver glutathione S-transferase mutant C47A complexed with S-(P-nitrobenzyl)glutathione
Template:ABSTRACT PUBMED 21134126
Function
[GSTP1_MOUSE] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Can metabolize 1-chloro-2,4-dinitrobenzene. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity).
About this Structure
3o76 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
See Also
Reference
- McManus G, Costa M, Canals A, Coll M, Mantle TJ. Site-directed mutagenesis of mouse glutathione transferase P1-1 unlocks masked cooperativity, introduces a novel mechanism for 'ping pong' kinetic behaviour, and provides further structural evidence for participation of a water molecule in proton abstraction from glutathione. FEBS J. 2011 Jan;278(2):273-81. doi: 10.1111/j.1742-4658.2010.07944.x., Epub 2010 Dec 6. PMID:21134126 doi:10.1111/j.1742-4658.2010.07944.x
