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Janus kinase
From Proteopedia
(New page: Crystal structure of JAK2 complex with inhibitor 3tjc {{STRUCTURE_3tjc| PDB=3tjc | SIZE=350| SCENE= |right|CAPTION=JAK2 complex with inhibitor [...) |
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[[Image:3tjc.png|left|200px|thumb|Crystal structure of JAK2 complex with inhibitor [[3tjc]]]] | [[Image:3tjc.png|left|200px|thumb|Crystal structure of JAK2 complex with inhibitor [[3tjc]]]] | ||
{{STRUCTURE_3tjc| PDB=3tjc | SIZE=350| SCENE= |right|CAPTION=JAK2 complex with inhibitor [[3tjc]] }} | {{STRUCTURE_3tjc| PDB=3tjc | SIZE=350| SCENE= |right|CAPTION=JAK2 complex with inhibitor [[3tjc]] }} | ||
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Revision as of 09:50, 25 April 2013
Janus kinase 2 (JAK2) is a nonreceptor tyrosine kinase which transduces cytokine-mediated signals via the JAK-STAT pathway. The JAK-STAT pathway transmits signals through the cell membrane to DNA promoters thus causing transcription. The name JAK is derived from Just Another Kinase. JAK proteins contain 2 phosphate-transfer domains, one with kinase activity using a phosphotyrosine (PTyr) and the other a pseudokinase domain which negatively regulates the kinase domain.
3D Structures of Janus kinase 2
Updated on 25-April-2013
JAK2 kinase domain
2b7a, 3fup, 4e6d, 4e6q, 4f08 – hJAK2 kinase domain (mutant) + PTyr + inhibitor - human
3ugc, 4bbe, 4bbf, 3zmm – hJAK2 kinase domain (mutant) + inhibitor
3e62, 3e63, 3e64, 2w1i, 3io7, 3iok, 3kck, 3jy9, 3lpb, 3krr, 3q32, 3tjc, 3tjd, 3rvg, 4aqc, 4e4m, 4f09, 4hge – hJAK2 kinase domain + PTyr + inhibitor
4gl9 – JAK2 kinase domain + PTyr + inhibitor + suppressor of cytokine signaling 3 + interleukin 6 receptor subunit β - mouse
JAK2 pseudokinase domain
3ugc – hJAK2 pseudokinase domain (mutant)
4fvq, 4fvr – hJAK2 pseudokinase domain (mutant) + ATP
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Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
