4i3q

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{{STRUCTURE_4i3q| PDB=4i3q | SCENE= }}
{{STRUCTURE_4i3q| PDB=4i3q | SCENE= }}
===Crystal structure of human CYP3A4 coordinated to a water molecule===
===Crystal structure of human CYP3A4 coordinated to a water molecule===
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{{ABSTRACT_PUBMED_23586711}}
==Function==
==Function==

Revision as of 06:32, 2 May 2013

Template:STRUCTURE 4i3q

Contents

Crystal structure of human CYP3A4 coordinated to a water molecule

Template:ABSTRACT PUBMED 23586711

Function

[CP3A4_HUMAN] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.[1]

About this Structure

4i3q is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Miyazawa M, Shindo M, Shimada T. Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from eucalyptus polybractea, by cytochrome P450 3A enzymes in rat and human liver microsomes. Drug Metab Dispos. 2001 Feb;29(2):200-5. PMID:11159812

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OCA

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