4iul

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==Function==
==Function==
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[[http://www.uniprot.org/uniprot/IF4G2_HUMAN IF4G2_HUMAN]] Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases.<ref>PMID:9049310</ref><ref>PMID:9032289</ref><ref>PMID:11511540</ref><ref>PMID:11943866</ref>
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[[http://www.uniprot.org/uniprot/IF4G2_HUMAN IF4G2_HUMAN]] Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases.<ref>PMID:9049310</ref> <ref>PMID:9032289</ref> <ref>PMID:11511540</ref> <ref>PMID:11943866</ref>
==About this Structure==
==About this Structure==

Revision as of 06:34, 2 May 2013

Template:STRUCTURE 4iul

Contents

MIF4G domain of DAP5

Template:ABSTRACT PUBMED 23478064

Function

[IF4G2_HUMAN] Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases.[1] [2] [3] [4]

About this Structure

4iul is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Imataka H, Olsen HS, Sonenberg N. A new translational regulator with homology to eukaryotic translation initiation factor 4G. EMBO J. 1997 Feb 17;16(4):817-25. PMID:9049310 doi:10.1093/emboj/16.4.817
  2. ↑ Levy-Strumpf N, Deiss LP, Berissi H, Kimchi A. DAP-5, a novel homolog of eukaryotic translation initiation factor 4G isolated as a putative modulator of gamma interferon-induced programmed cell death. Mol Cell Biol. 1997 Mar;17(3):1615-25. PMID:9032289
  3. ↑ Pyronnet S, Dostie J, Sonenberg N. Suppression of cap-dependent translation in mitosis. Genes Dev. 2001 Aug 15;15(16):2083-93. PMID:11511540 doi:10.1101/gad.889201
  4. ↑ Henis-Korenblit S, Shani G, Sines T, Marash L, Shohat G, Kimchi A. The caspase-cleaved DAP5 protein supports internal ribosome entry site-mediated translation of death proteins. Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5400-5. Epub 2002 Apr 9. PMID:11943866 doi:10.1073/pnas.082102499

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OCA

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