1xwy

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[[Image:1xwy.png|left|200px]]
 
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{{STRUCTURE_1xwy| PDB=1xwy | SCENE= }}
{{STRUCTURE_1xwy| PDB=1xwy | SCENE= }}
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===Crystal structure of tatD deoxyribonuclease from Escherichia coli K12 at 2.0 A resolution===
===Crystal structure of tatD deoxyribonuclease from Escherichia coli K12 at 2.0 A resolution===
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==Function==
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[[http://www.uniprot.org/uniprot/TATD_ECOLI TATD_ECOLI]] Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Although TatD is not required for export activity, it is a central component of a quality control system that is linked to the Tat translocation system. May act by degrading wild-type pre-protein molecules that are misfolded. Shows magnesium-dependent DNase activity.<ref>PMID:10747959</ref> <ref>PMID:19343049</ref>
==About this Structure==
==About this Structure==
[[1xwy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XWY OCA].
[[1xwy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XWY OCA].
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==Reference==
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<references group="xtra"/><references/>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Almo, S C.]]
[[Category: Almo, S C.]]

Revision as of 06:40, 2 May 2013

Template:STRUCTURE 1xwy

Contents

Crystal structure of tatD deoxyribonuclease from Escherichia coli K12 at 2.0 A resolution

Function

[TATD_ECOLI] Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Although TatD is not required for export activity, it is a central component of a quality control system that is linked to the Tat translocation system. May act by degrading wild-type pre-protein molecules that are misfolded. Shows magnesium-dependent DNase activity.[1] [2]

About this Structure

1xwy is a 1 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

  1. ↑ Wexler M, Sargent F, Jack RL, Stanley NR, Bogsch EG, Robinson C, Berks BC, Palmer T. TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export. J Biol Chem. 2000 Jun 2;275(22):16717-22. PMID:10747959 doi:10.1074/jbc.M000800200
  2. ↑ Matos CF, Di Cola A, Robinson C. TatD is a central component of a Tat translocon-initiated quality control system for exported FeS proteins in Escherichia coli. EMBO Rep. 2009 May;10(5):474-9. doi: 10.1038/embor.2009.34. Epub 2009 Apr 3. PMID:19343049 doi:10.1038/embor.2009.34

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