4i4h
From Proteopedia
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{{STRUCTURE_4i4h| PDB=4i4h | SCENE= }} | {{STRUCTURE_4i4h| PDB=4i4h | SCENE= }} | ||
===Crystal structure of CYP3A4 ligated to pyridine-substituted desoxyritonavir=== | ===Crystal structure of CYP3A4 ligated to pyridine-substituted desoxyritonavir=== | ||
| + | {{ABSTRACT_PUBMED_23586711}} | ||
==Function== | ==Function== | ||
Revision as of 06:42, 2 May 2013
Contents |
Crystal structure of CYP3A4 ligated to pyridine-substituted desoxyritonavir
Template:ABSTRACT PUBMED 23586711
Function
[CP3A4_HUMAN] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.[1]
About this Structure
4i4h is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
