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2f83
From Proteopedia
(Difference between revisions)
(New page: 200px<br /> <applet load="2f83" size="450" color="white" frame="true" align="right" spinBox="true" caption="2f83, resolution 2.87Å" /> '''Crystal structure o...) |
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| - | [[Image:2f83.gif|left|200px]]<br /> | + | [[Image:2f83.gif|left|200px]]<br /><applet load="2f83" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="2f83, resolution 2.87Å" /> | caption="2f83, resolution 2.87Å" /> | ||
'''Crystal structure of a human coagulation factor'''<br /> | '''Crystal structure of a human coagulation factor'''<br /> | ||
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| - | ==Overview== | ||
| - | Factor XI (FXI), a coagulation protein essential to normal hemostasis, circulates as a disulfide-linked dimer. Here we report the full-length FXI, zymogen crystal structure, revealing that the protease and four apple, domains assemble into a unique 'cup and saucer' architecture. The, structure shows that the thrombin and platelet glycoprotein Ib binding, sites are remote within the monomer but lie in close proximity across the, dimer, suggesting a transactivation mechanism. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2F83 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG and PT as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_XIa Coagulation factor XIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.27 3.4.21.27] Full crystallographic information is available from [http:// | + | 2F83 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> and <scene name='pdbligand=PT:'>PT</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_XIa Coagulation factor XIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.27 3.4.21.27] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F83 OCA]. |
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[[Category: Coagulation factor XIa]] | [[Category: Coagulation factor XIa]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Emsley, J.]] | [[Category: Emsley, J.]] | ||
| - | [[Category: McEwan, P | + | [[Category: McEwan, P A.]] |
[[Category: Papagrigoriou, E.]] | [[Category: Papagrigoriou, E.]] | ||
| - | [[Category: Walsh, P | + | [[Category: Walsh, P N.]] |
[[Category: NAG]] | [[Category: NAG]] | ||
[[Category: PT]] | [[Category: PT]] | ||
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[[Category: protease]] | [[Category: protease]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:21:40 2008'' |
Revision as of 15:21, 21 February 2008
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Crystal structure of a human coagulation factor
Disease
Known diseases associated with this structure: Factor XI deficiency, autosomal dominant OMIM:[264900], Factor XI deficiency, autosomal recessive OMIM:[264900]
About this Structure
2F83 is a Single protein structure of sequence from Homo sapiens with and as ligands. Active as Coagulation factor XIa, with EC number 3.4.21.27 Full crystallographic information is available from OCA.
Page seeded by OCA on Thu Feb 21 17:21:40 2008
