4ju0

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'''Unreleased structure'''
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{{STRUCTURE_4ju0| PDB=4ju0 | SCENE= }}
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===Crystal structure of 2009 pandemic influenza virus hemagglutinin mutant D225E complexed with human receptor analogue LSTc===
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{{ABSTRACT_PUBMED_23514882}}
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The entry 4ju0 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/C3W5S1_I09A0 C3W5S1_I09A0]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[SAAS:SAAS013829_004_327643][RuleBase:RU003324]
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Authors: Zhang, W., Shi, Y., Qi, J., Gao, F., Li, Q., Fan, Z., Yan, J., Gao, G.F.
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==About this Structure==
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[[4ju0]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/california/04/2009(h1n1)) Influenza a virus (a/california/04/2009(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JU0 OCA].
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Description: Crystal structure of 2009 pandemic influenza virus hemagglutinin mutant D225E complexed with human receptor analogue LSTc
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[[Category: Fan, Z.]]
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[[Category: Gao, F.]]
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[[Category: Gao, G F.]]
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[[Category: Li, Q.]]
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[[Category: Qi, J.]]
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[[Category: Shi, Y.]]
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[[Category: Yan, J.]]
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[[Category: Zhang, W.]]
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[[Category: Membrane fusion]]
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[[Category: Viral protein]]
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[[Category: Virus attachment]]

Revision as of 07:38, 2 May 2013

Template:STRUCTURE 4ju0

Crystal structure of 2009 pandemic influenza virus hemagglutinin mutant D225E complexed with human receptor analogue LSTc

Template:ABSTRACT PUBMED 23514882

Function

[C3W5S1_I09A0] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[SAAS:SAAS013829_004_327643][RuleBase:RU003324]

About this Structure

4ju0 is a 12 chain structure with sequence from Influenza a virus (a/california/04/2009(h1n1)). Full crystallographic information is available from OCA.

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OCA

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