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4j5p

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4j5p| PDB=4j5p | SCENE= }}
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===Crystal Structure of a Covalently Bound alpha-Ketoheterocycle Inhibitor (Phenhexyl/Oxadiazole/Pyridine) to a Humanized Variant of Fatty Acid Amide Hydrolase===
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{{ABSTRACT_PUBMED_23581831}}
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The entry 4j5p is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/FAAH1_RAT FAAH1_RAT]] Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity).
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Authors: Otrubova, K., Brown, M., McCormick, M.S., Han, G.W., O'Neal, S.T., Cravatt, B.F., Stevens, R.C., Lichtman, A.H., Boger, D.L.
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==About this Structure==
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[[4j5p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J5P OCA].
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Description: Crystal Structure of a Covalently Bound alpha-Ketoheterocycle Inhibitor (Phenhexyl/Oxadiazole/Pyridine) to a Humanized Variant of Fatty Acid Amide Hydrolase
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[[Category: Fatty acid amide hydrolase]]
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[[Category: Rattus norvegicus]]
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[[Category: Boger, D L.]]
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[[Category: Brown, M.]]
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[[Category: Cravatt, B F.]]
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[[Category: Han, G W.]]
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[[Category: Lichtman, A H.]]
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[[Category: McCormick, M S.]]
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[[Category: Neal, S T.O.]]
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[[Category: Otrubova, K.]]
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[[Category: Stevens, R C.]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]

Revision as of 07:40, 2 May 2013

Template:STRUCTURE 4j5p

Crystal Structure of a Covalently Bound alpha-Ketoheterocycle Inhibitor (Phenhexyl/Oxadiazole/Pyridine) to a Humanized Variant of Fatty Acid Amide Hydrolase

Template:ABSTRACT PUBMED 23581831

Function

[FAAH1_RAT] Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity).

About this Structure

4j5p is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

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OCA

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