4k1o
From Proteopedia
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- | + | {{STRUCTURE_4k1o| PDB=4k1o | SCENE= }} | |
+ | ===Crystal structure of the alphaN-catenin actin-binding domain=== | ||
+ | {{ABSTRACT_PUBMED_23589308}} | ||
- | + | ==Function== | |
+ | [[http://www.uniprot.org/uniprot/CTNA2_MOUSE CTNA2_MOUSE]] May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation.<ref>PMID:12089526</ref> <ref>PMID:12123610</ref> <ref>PMID:15034585</ref> | ||
- | + | ==About this Structure== | |
+ | [[4k1o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K1O OCA]. | ||
- | + | ==Reference== | |
+ | <references group="xtra"/><references/> | ||
+ | [[Category: Mus musculus]] | ||
+ | [[Category: Ikura, M.]] | ||
+ | [[Category: Ishiyama, N.]] | ||
+ | [[Category: Alpha-catenin]] | ||
+ | [[Category: Cell adhesion]] | ||
+ | [[Category: F-actin]] | ||
+ | [[Category: Five-helix bundle]] |
Revision as of 07:41, 2 May 2013
Contents |
Crystal structure of the alphaN-catenin actin-binding domain
Template:ABSTRACT PUBMED 23589308
Function
[CTNA2_MOUSE] May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation.[1] [2] [3]
About this Structure
4k1o is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- ↑ Park C, Falls W, Finger JH, Longo-Guess CM, Ackerman SL. Deletion in Catna2, encoding alpha N-catenin, causes cerebellar and hippocampal lamination defects and impaired startle modulation. Nat Genet. 2002 Jul;31(3):279-84. Epub 2002 Jun 24. PMID:12089526 doi:10.1038/ng908
- ↑ Togashi H, Abe K, Mizoguchi A, Takaoka K, Chisaka O, Takeichi M. Cadherin regulates dendritic spine morphogenesis. Neuron. 2002 Jul 3;35(1):77-89. PMID:12123610
- ↑ Abe K, Chisaka O, Van Roy F, Takeichi M. Stability of dendritic spines and synaptic contacts is controlled by alpha N-catenin. Nat Neurosci. 2004 Apr;7(4):357-63. Epub 2004 Mar 21. PMID:15034585 doi:10.1038/nn1212