4evt
From Proteopedia
| Line 1: | Line 1: | ||
| - | + | {{STRUCTURE_4evt| PDB=4evt | SCENE= }} | |
| + | ===Crystal Structure of Mouse Catenin beta-59 in 8.3M urea=== | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/CTNB1_MOUSE CTNB1_MOUSE]] Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (By similarity). | ||
| - | + | ==About this Structure== | |
| - | + | [[4evt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EVT OCA]. | |
| - | + | [[Category: Mus musculus]] | |
| + | [[Category: Wang, C.]] | ||
| + | [[Category: Zhang, G Y.]] | ||
| + | [[Category: Cell adhesion]] | ||
| + | [[Category: Mouse beta catenin]] | ||
| + | [[Category: Urea]] | ||
Revision as of 07:48, 2 May 2013
Crystal Structure of Mouse Catenin beta-59 in 8.3M urea
Function
[CTNB1_MOUSE] Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (By similarity).
About this Structure
4evt is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
