4iu6

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-	'''Unreleased structure'''	+	{{STRUCTURE_4iu6| PDB=4iu6 | SCENE= }}
		+	===Human Methionine Aminopeptidase in complex with FZ1: Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1===
-	The entry 4iu6 is ON HOLD until Paper Publication	+	==Function==
		+	[[http://www.uniprot.org/uniprot/AMPM1_HUMAN AMPM1_HUMAN]] Removes the N-terminal methionine from nascent proteins. Required for normal progression through the cell cycle.<ref>PMID:16274222</ref> <ref>PMID:17114291</ref>
-	Authors: Gabelli, S.B., Zhang, F., Miller, M., Liu, J., Amzel, L.M.	+	==About this Structure==
		+	[[4iu6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IU6 OCA].
-	Description: Human Methionine Aminopeptidase in complex with FZ1: Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1	+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Methionyl aminopeptidase]]
		+	[[Category: Amzel, L M.]]
		+	[[Category: Gabelli, S B.]]
		+	[[Category: Liu, J.]]
		+	[[Category: Miller, M.]]
		+	[[Category: Zhang, F.]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Metap1]]
		+	[[Category: Methionine aminopeptidase]]
		+	[[Category: Methionine aminopeptidase 1]]

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Revision as of 07:52, 2 May 2013

Template:STRUCTURE 4iu6

Contents 1 Human Methionine Aminopeptidase in complex with FZ1: Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1 2 Function 3 About this Structure 4 Reference

Human Methionine Aminopeptidase in complex with FZ1: Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1

Function

[AMPM1_HUMAN] Removes the N-terminal methionine from nascent proteins. Required for normal progression through the cell cycle.^{[1] [2]}

About this Structure

4iu6 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

1. ↑ Addlagatta A, Hu X, Liu JO, Matthews BW. Structural basis for the functional differences between type I and type II human methionine aminopeptidases. Biochemistry. 2005 Nov 15;44(45):14741-9. PMID:16274222 doi:10.1021/bi051691k
2. ↑ Hu X, Addlagatta A, Lu J, Matthews BW, Liu JO. Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18148-53. Epub 2006 Nov 17. PMID:17114291