2flb
From Proteopedia
(New page: 200px<br /> <applet load="2flb" size="450" color="white" frame="true" align="right" spinBox="true" caption="2flb, resolution 1.95Å" /> '''Discovery of a Nove...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:2flb.gif|left|200px]]<br /> | + | [[Image:2flb.gif|left|200px]]<br /><applet load="2flb" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2flb" size=" | + | |
caption="2flb, resolution 1.95Å" /> | caption="2flb, resolution 1.95Å" /> | ||
'''Discovery of a Novel Hydroxy Pyrazole Based Factor IXa Inhibitor'''<br /> | '''Discovery of a Novel Hydroxy Pyrazole Based Factor IXa Inhibitor'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Synthesis and biological data of a novel selective and efficacious factor | + | Synthesis and biological data of a novel selective and efficacious factor IXa inhibitor are described along with its crystal structure in factor VIIa. |
==Disease== | ==Disease== | ||
| Line 11: | Line 10: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2FLB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with 6NH as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 2FLB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=6NH:'>6NH</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLB OCA]. |
==Reference== | ==Reference== | ||
| Line 17: | Line 16: | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Katz, B | + | [[Category: Katz, B A.]] |
[[Category: 6NH]] | [[Category: 6NH]] | ||
[[Category: active site-directed]] | [[Category: active site-directed]] | ||
| Line 23: | Line 22: | ||
[[Category: short hydrogen bond-mediated]] | [[Category: short hydrogen bond-mediated]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:22:40 2008'' |
Revision as of 15:22, 21 February 2008
|
Discovery of a Novel Hydroxy Pyrazole Based Factor IXa Inhibitor
Contents |
Overview
Synthesis and biological data of a novel selective and efficacious factor IXa inhibitor are described along with its crystal structure in factor VIIa.
Disease
Known diseases associated with this structure: Esophageal squamous cell carcinoma OMIM:[606551], Factor VII deficiency OMIM:[227500], Myocardial infarction, decreased susceptibility to OMIM:[227500]
About this Structure
2FLB is a Protein complex structure of sequences from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Discovery of novel hydroxy pyrazole based factor IXa inhibitor., Vijaykumar D, Sprengeler PA, Shaghafi M, Spencer JR, Katz BA, Yu C, Rai R, Young WB, Schultz B, Janc J, Bioorg Med Chem Lett. 2006 May 15;16(10):2796-9. Epub 2006 Feb 17. PMID:16487703
Page seeded by OCA on Thu Feb 21 17:22:40 2008
