2flr
From Proteopedia
(New page: 200px<br /> <applet load="2flr" size="450" color="white" frame="true" align="right" spinBox="true" caption="2flr, resolution 2.35Å" /> '''Novel 5-Azaindole F...) |
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| - | [[Image:2flr.gif|left|200px]]<br /> | + | [[Image:2flr.gif|left|200px]]<br /><applet load="2flr" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2flr" size=" | + | |
caption="2flr, resolution 2.35Å" /> | caption="2flr, resolution 2.35Å" /> | ||
'''Novel 5-Azaindole Factor VIIa Inhibitors'''<br /> | '''Novel 5-Azaindole Factor VIIa Inhibitors'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The discovery and development of 5-azaindole factor VIIa inhibitors will | + | The discovery and development of 5-azaindole factor VIIa inhibitors will be described. |
==Disease== | ==Disease== | ||
| Line 11: | Line 10: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2FLR is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with 7NH as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21] Full crystallographic information is available from [http:// | + | 2FLR is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=7NH:'>7NH</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLR OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Green, M | + | [[Category: Green, M J.]] |
[[Category: Hu, H.]] | [[Category: Hu, H.]] | ||
| - | [[Category: Katz, B | + | [[Category: Katz, B A.]] |
[[Category: Kolesnikov, A.]] | [[Category: Kolesnikov, A.]] | ||
| - | [[Category: Leahy, E | + | [[Category: Leahy, E M.]] |
| - | [[Category: Riggs, J | + | [[Category: Riggs, J R.]] |
| - | [[Category: Shrader, W | + | [[Category: Shrader, W D.]] |
| - | [[Category: Sprengeler, P | + | [[Category: Sprengeler, P A.]] |
[[Category: Tong, Z.]] | [[Category: Tong, Z.]] | ||
[[Category: Vijaykumar, D.]] | [[Category: Vijaykumar, D.]] | ||
| - | [[Category: Wahl, T | + | [[Category: Wahl, T A.]] |
| - | [[Category: Wesson, K | + | [[Category: Wesson, K E.]] |
| - | [[Category: Young, W | + | [[Category: Young, W B.]] |
[[Category: Yu, C.]] | [[Category: Yu, C.]] | ||
[[Category: 7NH]] | [[Category: 7NH]] | ||
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[[Category: short hydrogen bond]] | [[Category: short hydrogen bond]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:22:43 2008'' |
Revision as of 15:22, 21 February 2008
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Novel 5-Azaindole Factor VIIa Inhibitors
Contents |
Overview
The discovery and development of 5-azaindole factor VIIa inhibitors will be described.
Disease
Known diseases associated with this structure: Esophageal squamous cell carcinoma OMIM:[606551], Factor VII deficiency OMIM:[227500], Myocardial infarction, decreased susceptibility to OMIM:[227500]
About this Structure
2FLR is a Protein complex structure of sequences from Homo sapiens with as ligand. Active as Coagulation factor VIIa, with EC number 3.4.21.21 Full crystallographic information is available from OCA.
Reference
Novel 5-azaindole factor VIIa inhibitors., Riggs JR, Hu H, Kolesnikov A, Leahy EM, Wesson KE, Shrader WD, Vijaykumar D, Wahl TA, Tong Z, Sprengeler PA, Green MJ, Yu C, Katz BA, Sanford E, Nguyen M, Cabuslay R, Young WB, Bioorg Med Chem Lett. 2006 Jun 15;16(12):3197-200. Epub 2006 Apr 18. PMID:16621549
Page seeded by OCA on Thu Feb 21 17:22:43 2008
Categories: Coagulation factor VIIa | Homo sapiens | Protein complex | Green, M J. | Hu, H. | Katz, B A. | Kolesnikov, A. | Leahy, E M. | Riggs, J R. | Shrader, W D. | Sprengeler, P A. | Tong, Z. | Vijaykumar, D. | Wahl, T A. | Wesson, K E. | Young, W B. | Yu, C. | 7NH | 5-azaindole inhibitors | S1 site | Short hydrogen bond
