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3p8p
From Proteopedia
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{{STRUCTURE_3p8p| PDB=3p8p | SCENE= }} | {{STRUCTURE_3p8p| PDB=3p8p | SCENE= }} | ||
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===Crystal Structure of Human Dimethylarginine Dimethylaminohydrolase-1 (DDAH-1) variant C274S bound with N5-(1-iminopentyl)-L-ornithine=== | ===Crystal Structure of Human Dimethylarginine Dimethylaminohydrolase-1 (DDAH-1) variant C274S bound with N5-(1-iminopentyl)-L-ornithine=== | ||
| + | {{ABSTRACT_PUBMED_20979083}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/DDAH1_HUMAN DDAH1_HUMAN]] Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. | |
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:020979083</ref><references group="xtra"/><references/> |
[[Category: Dimethylargininase]] | [[Category: Dimethylargininase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
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[[Category: Robertus, J D.]] | [[Category: Robertus, J D.]] | ||
[[Category: Wang, Y.]] | [[Category: Wang, Y.]] | ||
| + | [[Category: Ddah]] | ||
| + | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
| + | [[Category: Nitric oxide synthase regulator]] | ||
Revision as of 08:11, 2 May 2013
Contents |
Crystal Structure of Human Dimethylarginine Dimethylaminohydrolase-1 (DDAH-1) variant C274S bound with N5-(1-iminopentyl)-L-ornithine
Template:ABSTRACT PUBMED 20979083
Function
[DDAH1_HUMAN] Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.
About this Structure
3p8p is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Lluis M, Wang Y, Monzingo AF, Fast W, Robertus JD. Characterization of C-Alkyl Amidines as Bioavailable Covalent Reversible Inhibitors of Human DDAH-1. ChemMedChem. 2010 Oct 26. PMID:20979083 doi:10.1002/cmdc.201000392
