3ope

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[[Image:3ope.jpg|left|200px]]
 
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{{STRUCTURE_3ope| PDB=3ope | SCENE= }}
{{STRUCTURE_3ope| PDB=3ope | SCENE= }}
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===Structural Basis of Auto-inhibitory mechanism of Histone methyltransferase===
===Structural Basis of Auto-inhibitory mechanism of Histone methyltransferase===
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{{ABSTRACT_PUBMED_021239497}}
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==Function==
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[[http://www.uniprot.org/uniprot/ASH1L_HUMAN ASH1L_HUMAN]] Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me).<ref>PMID:21239497</ref>
==About this Structure==
==About this Structure==
[[3ope]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OPE OCA].
[[3ope]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OPE OCA].
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==Reference==
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<references group="xtra"/><references/>
[[Category: Histone-lysine N-methyltransferase]]
[[Category: Histone-lysine N-methyltransferase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: An, S.]]
[[Category: An, S.]]
[[Category: Song, J.]]
[[Category: Song, J.]]
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[[Category: Methyltransferase]]
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[[Category: Nucleus]]
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[[Category: Set]]
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[[Category: Transferase]]

Revision as of 08:11, 2 May 2013

Template:STRUCTURE 3ope

Contents

Structural Basis of Auto-inhibitory mechanism of Histone methyltransferase

Template:ABSTRACT PUBMED 021239497

Function

[ASH1L_HUMAN] Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me).[1]

About this Structure

3ope is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. An S, Yeo KJ, Jeon YH, Song JJ. Crystal structure of the human histone methyltransferase ASH1L catalytic domain and its implications for the regulatory mechanism. J Biol Chem. 2011 Mar 11;286(10):8369-74. Epub 2011 Jan 14. PMID:21239497 doi:10.1074/jbc.M110.203380

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