3p5p

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[[Image:3p5p.png|left|200px]]
 
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{{STRUCTURE_3p5p| PDB=3p5p | SCENE= }}
{{STRUCTURE_3p5p| PDB=3p5p | SCENE= }}
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===Crystal Structure of Taxadiene Synthase from Pacific Yew (Taxus brevifolia) in complex with Mg2+ and 13-aza-13,14-dihydrocopalyl diphosphate===
===Crystal Structure of Taxadiene Synthase from Pacific Yew (Taxus brevifolia) in complex with Mg2+ and 13-aza-13,14-dihydrocopalyl diphosphate===
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{{ABSTRACT_PUBMED_21160477}}
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==Function==
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[[http://www.uniprot.org/uniprot/TASY_TAXBR TASY_TAXBR]] Catalyzes the cyclization of the ubiquitous isoprenoid intermediate geranylgeranyl diphosphate to taxa-4,11-diene, the parent olefin with a taxane skeleton.
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The line below this paragraph, {{ABSTRACT_PUBMED_21160477}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 21160477 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21160477}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:21160477</ref><references group="xtra"/>
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<ref group="xtra">PMID:021160477</ref><references group="xtra"/><references/>
[[Category: Taxadiene synthase]]
[[Category: Taxadiene synthase]]
[[Category: Taxus brevifolia]]
[[Category: Taxus brevifolia]]
[[Category: Christianson, D W.]]
[[Category: Christianson, D W.]]
[[Category: Koksal, M.]]
[[Category: Koksal, M.]]
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[[Category: 3-azacopalyl diphosphate]]
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[[Category: Biosynthesis of paclitaxel]]
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[[Category: Class i and ii terpene cyclase fold]]
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[[Category: Ddxxd motif]]
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[[Category: Diterpene cyclase]]
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[[Category: Lyase]]
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[[Category: Nse/dte motif]]

Revision as of 08:18, 2 May 2013

Template:STRUCTURE 3p5p

Contents

Crystal Structure of Taxadiene Synthase from Pacific Yew (Taxus brevifolia) in complex with Mg2+ and 13-aza-13,14-dihydrocopalyl diphosphate

Template:ABSTRACT PUBMED 21160477

Function

[TASY_TAXBR] Catalyzes the cyclization of the ubiquitous isoprenoid intermediate geranylgeranyl diphosphate to taxa-4,11-diene, the parent olefin with a taxane skeleton.

About this Structure

3p5p is a 1 chain structure with sequence from Taxus brevifolia. Full crystallographic information is available from OCA.

Reference

  • Koksal M, Jin Y, Coates RM, Croteau R, Christianson DW. Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis. Nature. 2010 Dec 15. PMID:21160477 doi:10.1038/nature09628

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