3pdt

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m (Protected "3pdt" [edit=sysop:move=sysop])
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[[Image:3pdt.png|left|200px]]
 
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{{STRUCTURE_3pdt| PDB=3pdt | SCENE= }}
{{STRUCTURE_3pdt| PDB=3pdt | SCENE= }}
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===Crystal Structure of the C-terminal Truncated Alpha-Kinase Domain of Myosin Heavy chain Kinase===
===Crystal Structure of the C-terminal Truncated Alpha-Kinase Domain of Myosin Heavy chain Kinase===
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{{ABSTRACT_PUBMED_21071445}}
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==Function==
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[[http://www.uniprot.org/uniprot/MHCKA_DICDI MHCKA_DICDI]] Phosphorylates threonine in the C-terminal tail region of myosin II heavy chain. This phosphorylation is critical in regulating the assembly and disassembly of myosin II filament. Requires autophosphorylation for activity.
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{{ABSTRACT_PUBMED_21071445}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:21071445</ref><references group="xtra"/>
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<ref group="xtra">PMID:021071445</ref><ref group="xtra">PMID:018650931</ref><references group="xtra"/><references/>
[[Category: Dictyostelium discoideum]]
[[Category: Dictyostelium discoideum]]
[[Category: Jia, Z.]]
[[Category: Jia, Z.]]
[[Category: Ye, Q.]]
[[Category: Ye, Q.]]
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[[Category: Alpha-kinase]]
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[[Category: Atp binding]]
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[[Category: Nucleotide binding]]
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[[Category: Protein kinase]]
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[[Category: Protein kinase like fold]]
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[[Category: Serine/threonine kinase]]
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[[Category: Transferase]]

Revision as of 08:20, 2 May 2013

Template:STRUCTURE 3pdt

Contents

Crystal Structure of the C-terminal Truncated Alpha-Kinase Domain of Myosin Heavy chain Kinase

Template:ABSTRACT PUBMED 21071445

Function

[MHCKA_DICDI] Phosphorylates threonine in the C-terminal tail region of myosin II heavy chain. This phosphorylation is critical in regulating the assembly and disassembly of myosin II filament. Requires autophosphorylation for activity.

About this Structure

3pdt is a 1 chain structure with sequence from Dictyostelium discoideum. Full crystallographic information is available from OCA.

Reference

  • Crawley SW, Samimi Gharaei M, Ye Q, Yang Y, Raveh B, London N, Schueler-Furman O, Jia Z, Cote GP. Autophosphorylation activates Dictyostelium myosin II heavy chain kinase A by providing a ligand for an allosteric binding site in the {alpha}-kinase domain. J Biol Chem. 2010 Nov 11. PMID:21071445 doi:10.1074/jbc.M110.177014
  • Gotthardt K, Weyand M, Kortholt A, Van Haastert PJ, Wittinghofer A. Structure of the Roc-COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase. EMBO J. 2008 Aug 20;27(16):2239-49. Epub 2008 Jul 24. PMID:18650931 doi:10.1038/emboj.2008.150

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OCA

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