3p7j

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[[Image:3p7j.png|left|200px]]
 
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{{STRUCTURE_3p7j| PDB=3p7j | SCENE= }}
{{STRUCTURE_3p7j| PDB=3p7j | SCENE= }}
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===Drosophila HP1a chromo shadow domain===
===Drosophila HP1a chromo shadow domain===
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{{ABSTRACT_PUBMED_21472955}}
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==Function==
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[[http://www.uniprot.org/uniprot/HP1_DROME HP1_DROME]] Structural component of heterochromatin, involved in gene repression and the modification of position-effect-variegation. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression.
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{{ABSTRACT_PUBMED_21472955}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:021472955</ref><references group="xtra"/>
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<ref group="xtra">PMID:021472955</ref><references group="xtra"/><references/>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
[[Category: Chruszcz, M.]]
[[Category: Chruszcz, M.]]
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[[Category: Kim, D.]]
[[Category: Kim, D.]]
[[Category: Minor, W.]]
[[Category: Minor, W.]]
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[[Category: Chromo shadow domain]]
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[[Category: Epigenetic]]
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[[Category: Gene silencing]]
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[[Category: Heterochromatin protein 1]]
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[[Category: Transcription]]

Revision as of 08:22, 2 May 2013

Template:STRUCTURE 3p7j

Contents

Drosophila HP1a chromo shadow domain

Template:ABSTRACT PUBMED 21472955

Function

[HP1_DROME] Structural component of heterochromatin, involved in gene repression and the modification of position-effect-variegation. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression.

About this Structure

3p7j is a 2 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

  • Mendez DL, Kim D, Chruszcz M, Stephens GE, Minor W, Khorasanizadeh S, Elgin SC. The HP1a Disordered C Terminus and Chromo Shadow Domain Cooperate to Select Target Peptide Partners. Chembiochem. 2011 May 2;12(7):1084-96. doi: 10.1002/cbic.201000598. Epub, 2011 Apr 5. PMID:21472955 doi:10.1002/cbic.201000598

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OCA

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