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3p76
From Proteopedia
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{{STRUCTURE_3p76| PDB=3p76 | SCENE= }} | {{STRUCTURE_3p76| PDB=3p76 | SCENE= }} | ||
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===X-ray crystal structure of Aquifex aeolicus LpxC complexed SCH1379777=== | ===X-ray crystal structure of Aquifex aeolicus LpxC complexed SCH1379777=== | ||
| + | {{ABSTRACT_PUBMED_21273067}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/LPXC_AQUAE LPXC_AQUAE]] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity). | |
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:021273067</ref><references group="xtra"/><references/> |
[[Category: Aquifex aeolicus]] | [[Category: Aquifex aeolicus]] | ||
[[Category: Orth, P.]] | [[Category: Orth, P.]] | ||
| + | [[Category: Amidohydrolase]] | ||
| + | [[Category: Amino acid motif]] | ||
| + | [[Category: Binding site]] | ||
| + | [[Category: Drug design]] | ||
| + | [[Category: Enzyme inhibitor]] | ||
| + | [[Category: Escherichia coli protein]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Hydrophobicity]] | ||
| + | [[Category: Lipid some]] | ||
| + | [[Category: Protein conformation]] | ||
| + | [[Category: Protein folding]] | ||
| + | [[Category: Recombinant fusion protein]] | ||
| + | [[Category: Structure-activity relationship]] | ||
Revision as of 08:23, 2 May 2013
Contents |
X-ray crystal structure of Aquifex aeolicus LpxC complexed SCH1379777
Template:ABSTRACT PUBMED 21273067
Function
[LPXC_AQUAE] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity).
About this Structure
3p76 is a 1 chain structure with sequence from Aquifex aeolicus. Full crystallographic information is available from OCA.
Reference
- Faruk Mansoor U, Vitharana D, Reddy PA, Daubaras DL, McNicholas P, Orth P, Black T, Arshad Siddiqui M. Design and synthesis of potent Gram-negative specific LpxC inhibitors. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1155-61. Epub 2010 Dec 28. PMID:21273067 doi:10.1016/j.bmcl.2010.12.111
