3ote

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[[Image:3ote.png|left|200px]]
 
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{{STRUCTURE_3ote| PDB=3ote | SCENE= }}
{{STRUCTURE_3ote| PDB=3ote | SCENE= }}
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===Crystal structure of human tRNAHis guanylyltransferase (Thg1)- Native I===
===Crystal structure of human tRNAHis guanylyltransferase (Thg1)- Native I===
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{{ABSTRACT_PUBMED_21059936}}
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==Function==
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[[http://www.uniprot.org/uniprot/THG1_HUMAN THG1_HUMAN]] Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis.<ref>PMID:21059936</ref>
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{{ABSTRACT_PUBMED_21059936}}
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==About this Structure==
==About this Structure==
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3OTE is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OTE OCA].
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[[3ote]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OTE OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:21059936</ref><references group="xtra"/>
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<ref group="xtra">PMID:021059936</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Doublie, S.]]
[[Category: Doublie, S.]]
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[[Category: Polymerase-like palm domain]]
[[Category: Polymerase-like palm domain]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 8 11:21:55 2010''
 

Revision as of 08:23, 2 May 2013

Template:STRUCTURE 3ote

Contents

Crystal structure of human tRNAHis guanylyltransferase (Thg1)- Native I

Template:ABSTRACT PUBMED 21059936

Function

[THG1_HUMAN] Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis.[1]

About this Structure

3ote is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Hyde SJ, Eckenroth BE, Smith BA, Eberley WA, Heintz NH, Jackman JE, Doublie S. tRNAHis guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'-3' DNA polymerases. Proc Natl Acad Sci U S A. 2010 Nov 8. PMID:21059936 doi:10.1073/pnas.1010436107
  1. ↑ Hyde SJ, Eckenroth BE, Smith BA, Eberley WA, Heintz NH, Jackman JE, Doublie S. tRNAHis guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'-3' DNA polymerases. Proc Natl Acad Sci U S A. 2010 Nov 8. PMID:21059936 doi:10.1073/pnas.1010436107

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