3ote

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3ote" [edit=sysop:move=sysop])

Revision as of 08:23, 2 May 2013

Template:STRUCTURE 3ote

Contents

Crystal structure of human tRNAHis guanylyltransferase (Thg1)- Native I

Template:ABSTRACT PUBMED 21059936

Function

[THG1_HUMAN] Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis.[1]

About this Structure

3ote is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Hyde SJ, Eckenroth BE, Smith BA, Eberley WA, Heintz NH, Jackman JE, Doublie S. tRNAHis guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'-3' DNA polymerases. Proc Natl Acad Sci U S A. 2010 Nov 8. PMID:21059936 doi:10.1073/pnas.1010436107
  1. Hyde SJ, Eckenroth BE, Smith BA, Eberley WA, Heintz NH, Jackman JE, Doublie S. tRNAHis guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'-3' DNA polymerases. Proc Natl Acad Sci U S A. 2010 Nov 8. PMID:21059936 doi:10.1073/pnas.1010436107

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools