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3par
From Proteopedia
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| - | [[Image:3par.png|left|200px]] | ||
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{{STRUCTURE_3par| PDB=3par | SCENE= }} | {{STRUCTURE_3par| PDB=3par | SCENE= }} | ||
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===Surfactant Protein-A neck and carbohydrate recognition domain (NCRD) in the absence of ligand=== | ===Surfactant Protein-A neck and carbohydrate recognition domain (NCRD) in the absence of ligand=== | ||
| + | {{ABSTRACT_PUBMED_21047777}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/SFTPA_RAT SFTPA_RAT]] In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. | |
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:021047777</ref><references group="xtra"/><references/> |
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Cafarella, T M.]] | [[Category: Cafarella, T M.]] | ||
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[[Category: Shang, F.]] | [[Category: Shang, F.]] | ||
[[Category: Wu, H.]] | [[Category: Wu, H.]] | ||
| + | [[Category: Carbohydrate binding]] | ||
| + | [[Category: Collectin]] | ||
| + | [[Category: Lectin]] | ||
| + | [[Category: Mannose]] | ||
| + | [[Category: Sugar binding protein]] | ||
Revision as of 08:28, 2 May 2013
Contents |
Surfactant Protein-A neck and carbohydrate recognition domain (NCRD) in the absence of ligand
Template:ABSTRACT PUBMED 21047777
Function
[SFTPA_RAT] In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.
About this Structure
3par is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
- Shang F, Rynkiewicz MJ, McCormack FX, Wu H, Cafarella TM, Head JF, Seaton BA. Crystallographic Complexes of Surfactant Protein A and Carbohydrates Reveal Ligand-induced Conformational Change. J Biol Chem. 2011 Jan 7;286(1):757-65. Epub 2010 Nov 3. PMID:21047777 doi:10.1074/jbc.M110.175265
