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3oxo
From Proteopedia
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| - | [[Image:3oxo.png|left|200px]] | ||
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{{STRUCTURE_3oxo| PDB=3oxo | SCENE= }} | {{STRUCTURE_3oxo| PDB=3oxo | SCENE= }} | ||
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===Succinyl-CoA:3-ketoacid CoA transferase from pig heart covalently bound to CoA=== | ===Succinyl-CoA:3-ketoacid CoA transferase from pig heart covalently bound to CoA=== | ||
| + | {{ABSTRACT_PUBMED_20977214}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/SCOT1_PIG SCOT1_PIG]] Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | |
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:020977214</ref><references group="xtra"/><references/> |
[[Category: 3-oxoacid CoA-transferase]] | [[Category: 3-oxoacid CoA-transferase]] | ||
[[Category: Sus scrofa]] | [[Category: Sus scrofa]] | ||
[[Category: Fraser, M E.]] | [[Category: Fraser, M E.]] | ||
| + | [[Category: Alpha/beta protein]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 08:29, 2 May 2013
Contents |
Succinyl-CoA:3-ketoacid CoA transferase from pig heart covalently bound to CoA
Template:ABSTRACT PUBMED 20977214
Function
[SCOT1_PIG] Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
About this Structure
3oxo is a 8 chain structure with sequence from Sus scrofa. Full crystallographic information is available from OCA.
Reference
- Fraser ME, Hayakawa K, Brown WD. Catalytic Role of the Conformational Change in Succinyl-CoA:3-Oxoacid CoA Transferase on Binding CoA. Biochemistry. 2010 Oct 26. PMID:20977214 doi:10.1021/bi100659s
