3p8e

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m (Protected "3p8e" [edit=sysop:move=sysop])
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[[Image:3p8e.png|left|200px]]
 
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{{STRUCTURE_3p8e| PDB=3p8e | SCENE= }}
{{STRUCTURE_3p8e| PDB=3p8e | SCENE= }}
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===Crystal structure of human DIMETHYLARGININE DIMETHYLAMINOHYDROLASE-1 (DDAH-1) covalently bound with N5-(1-iminopentyl)-L-ornithine===
===Crystal structure of human DIMETHYLARGININE DIMETHYLAMINOHYDROLASE-1 (DDAH-1) covalently bound with N5-(1-iminopentyl)-L-ornithine===
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{{ABSTRACT_PUBMED_20979083}}
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==Function==
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[[http://www.uniprot.org/uniprot/DDAH1_HUMAN DDAH1_HUMAN]] Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.
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{{ABSTRACT_PUBMED_20979083}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:20979083</ref><references group="xtra"/>
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<ref group="xtra">PMID:020979083</ref><references group="xtra"/><references/>
[[Category: Dimethylargininase]]
[[Category: Dimethylargininase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Robertus, J D.]]
[[Category: Robertus, J D.]]
[[Category: Wang, Y.]]
[[Category: Wang, Y.]]
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[[Category: Ddah]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Nitric oxide synthase regulation]]

Revision as of 08:31, 2 May 2013

Template:STRUCTURE 3p8e

Contents

Crystal structure of human DIMETHYLARGININE DIMETHYLAMINOHYDROLASE-1 (DDAH-1) covalently bound with N5-(1-iminopentyl)-L-ornithine

Template:ABSTRACT PUBMED 20979083

Function

[DDAH1_HUMAN] Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

About this Structure

3p8e is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Lluis M, Wang Y, Monzingo AF, Fast W, Robertus JD. Characterization of C-Alkyl Amidines as Bioavailable Covalent Reversible Inhibitors of Human DDAH-1. ChemMedChem. 2010 Oct 26. PMID:20979083 doi:10.1002/cmdc.201000392

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OCA

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